Has anyone experienced more pain when first given prednisone for RA? I have taken Prednisone other times for respiratory issues with no problems. My dr. prescribed Prednisone while in the process of determining if I do indeed have full blown RA. I have been on 15mg for two days and my pain has gotten worse. Previously I had severe constant pain in my hands and more minor pain in ankles, hips, and neck. Now I am hurting at my knees, wrists, shoulders... not to mention the previous pain is still there.