When I fill my monthly generic prescription for oxycodone, I sometimes get pills made by different manufacturers. It seems like some work better than others, same dose - same drug! Does anyone else have this experience?
2 Jul 2013
I don't feel any difference betwixt my generic oxycodone, but hang in there, others will agree with you I'm quite sure.
Do you've a preference of manufacturers? If so, talk to your pharmacist to see if they'll order your favourite just for you, it may work!
Best wishes to you,
2 Jul 2013
I read on WebMD recently, that manufacturers of generic drugs have to have the same "main ingredients" as Brand name. They can add coloring, or change size and shape, but, otherwise have to work like the Brand. I have been taking meds for over 28+ yrs and some Brands feel better, but, most generics work just fine. Generics have to pass same regulations that Brand names do. Basically there is very little difference, and from what I read, must "act" in the same manner. WebMd is a pretty good source of info. Look it up there if you can for more info. Its not as personal as this site, but, they do have updated info on most anything you can think of. I like it here best because not only do I get information, I get ideas, reactions, personal experience, and so far, the people are really nice and smart. Still, basic Information is good to have too. Ta ke care and be well as can be...
6 Mar 2014
I have this exact same problem! Most generic brands of the 5mg oxycodone cause me a lot of problems... mainly itching and sever heartburn... I asked my doctor about this and he explained that it' s most likely not the oxycodone in it but the inert added ingredients that these generic manufactures put in as filler. I also asked why I can not always get the brand that does not cause me any problems or side effects, I asked my regular pharmacist and was told that the "big box" store where I get my prescriptions filled, is constantly shopping around for the cheapest deal on the scripts that they carry! So far the worst brand I have found is Caraco.
It makes me as sick as a dog, but I have no choice but to take it, if I go to a different pharmacy, my doctor gets upset and threatens to dump me as a patient! Also some of the cheaper generic brands use a whole lot of extra inert fillers, to make their product cheaper therefore the pharmacies will buy from them more often, even though the drugs are supposed to be identical... we all know they are not! And no, this brand does not work as well as some others do, all drugs are not created equal!
17 Oct 2014
People including doctors and pharmacist will say they are the same claiming legally they have to be the same up to a slight legal difference that shouldn't be noticeable. I don't care what they say as someone that has taken them and know a lot of other people that do as well they do not all work as well. I will say most are the same can't even tell the difference but their are a few that fail and I mean by a lot. Some I can take quite a few of them more than prescribed and still nothing. I don't know how they get away with it. I'm speaking of the 10 mg ones and specifically the ones that have A333 and IP203 on them really suck. They should be investigated because they are cheating people.
13 Dec 2014
While the amount of active ingredient is standardized across all generic formulations of any particular drug, due to variable excipients and formulation between different generic products, it is likely that different generic formulations will exhibit differences in drug bioavailability (which is ultimately a function of drug absorption, distribution, metabolism and elimination)- which will be influenced by the composition of the formulation.
31 Dec 2014
There is definitely a difference. All controlled substances have a number and letter or just numbers on it. Go to the area in drugs. com and type in the identifying number and or letters and it will tell you the ingredients. Way different and some don't have the ingredient of the ones that help
9 Oct 2015
I have the same response to taking the oxycodone with the letter M*s 30 milligrams does not work for me I asked my doctor what is the difference in the lettering cuz the A*s work better for me and the k9*s work better for me. I wonder do they put different medicines in at different manufacturer if anybody knows the answer please let me know cause i have to go look for what works for me every month when it time for my refil.
15 Nov 2015
Today even my doctors know that due to Obama care that yes,the generic alternatives are different from the brand name medications ,it is definitely not in your head,before you buy a generic equalivant I would advise you to google and find what works best for most people,the fda does not regulate the fillers that are added to the generic equalivant medications,some people are blind to the fact that the pharmaceutical industry is larger than any business,if the government has their way they will import the cheapest drugs from countries like China,India Japan,even though the active ingredient is equal,the fillers are different,why?Because the fillers act differently and are not absorbed properly in most people,they are left to show their own independent studies and report back to the fda,the government can buy boatloads of medication for a far cheaper price than most manfacturers can afford,let's face it,our healthcare system is in big trouble and cuts are being made every day in ...
order for it to stay afloat,cost are being cut across the board and some people still believe that generates are exactly the same,for those who choose to believe that their is no difference,do some research and if you dig deep enough,you will find it in black and white,there is a difference,and many people are beginning to find out that some of the medication is not working like it did in the past,cost cutting is indeed being applied,and it is making people sick,my advice is to be more proactive and find out what works best for you and definitely go with your instincts,then you don't have to listen to the so-called generic drugs are the same,because that is just not so,Cane0716
8 Mar 2016
It is not in your head! I have been taking oxycodone and oxycontin for more years than I care to admit. There is a difference. There are at least half a dozen manufactures and 4 to 5 different number designations. A333 seems to work the best. There's another one that starts with IP which is pretty good too. They one to stay away from is the one that is about the same length as a Tylenol (the others are shorter). I actually got so tired of it that I had my doctor switch me to the straight oxycodone with no Tylenol in it. Those pills are consistent and I needed a stronger dose anyway and 10mg is the biggest one that includes Tylenol. The 20mg and 30mg pills are straight oxycodone, nothing else.
21 Apr 2016
My Pain Management doctor says the FDA gives them 25% wiggle room. So, depending on the batch, for a 10 mg pill, you could get 7.5-12.5.
I had some Percocet that were terrible. I switched to Oxycodone alone because I figure with fewer ingredients you had a better chance of getting the oxy.
When you are in pain, it really matters that it is right!
3 Jun 2016
Thanks guys. I have the same experience. One generic makes me sick, another one is far weaker. The doctor changed my pain meds - we are taking away the APAP so I will be trying Oxycodone for the first time - and I'm scared about getting a bad brand and having to get through a month or more finding a brand that I can tolerate and will work. Sometimes they are so weak that even doubling the dose - always letting the MD know - doesn't add up to one tablet of the better brand.
8 Jun 2016
Hi I've been on oxycodone 10 mill for years and so is my husband. We can both tell a huge difference. The yellow generic ones with 230 and a C on one side I'd far better than any other brand. And they are a generic brand. I think called Alvogen. Does anyone else feel this way? And how can I look up all the ingredients on the the one I like and the ones i dont and compare them just for my knowledge?
14 Jun 2016
I just switched from qualitest to macrinkodt 30 mg oxycodone and they do seem stronger than others I have tried like mylan and qualitest. I have been in pain management for over two years and these seem the best to me. A person does build up a tolerance after a while so switching brands ever so often may help.
20 days ago
It is interesting reading everyone`s input., but has anyone ever had the "generic" oxycodone independently tested by a govt. registered laboratory. It seems everyone assumes the same thing- that the tabsule they are taking has been manufactured by a reputable company... Has anyone checked further up the "manufacturing chain" Where does the pill manufacturer source his supply of oxycodone from? He might be quite genuine in what he is making, but what if in his effort to source "cheaper" ingredients, he could be using from a substandard source! I have just had the experience in hospital of having a dose of Endone which should have knocked an elephant flat, but in reality I may as well have swallowed chalk..perhaps that IS all it was? How do I find out... I think then ,that there is two answers to your question- 1 There is no difference between the active ingredients of generics THIS IS THE LAW!
2.The only way to find out, is to have the various substances laboratory tested.
To illustrate the point I am making- I also discovered that often times that 100metre rolls of adhesive tape usually only have 93metres or less (BUT NO-ONE EVER UNROLLS A NEW ROLL OF TAPE TO CHECK, I was the first person evidently to do this ) . The same with toilet paper -whoever checks that a new roll of toilet paper is as long as the label says? That a tin of Chicken & vegetable soup really has 20% chicken (by weight), that the label claims? (I checked 4 different brands and not one came anywhere to the claimed meat content)
Often products are imported from other countries which do not have the same regard for standards as we do.
The same goes for drug manufacturing. Fortunately we do have laws in this country to protect us... but how often do we read in the media of URGENT RECALLS of various drugs due to issues in manufacturing... mostly we are not told where they have been made, only what the problem is.
We only see the end product . We do not know how it was made, how much it cost to manufacture, the cost of development, etc... but every one wants to save money, the manufacturer , the wholesaler, the retailer and the buyer!
- Oxycodone Information for Consumers
- Oxycodone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Oxycodone (detailed)
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