Metoprolol - Is it safe for people with CHF?
Question posted by micahshema on 9 Oct 2022
Last updated on 9 October 2022 by masso
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Answers
Major
Beta-blockers (applies to metoprolol) CHF
Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure
Beta-adrenergic receptor blocking agents (aka beta-blockers) in general should not be used in patients with overt congestive heart failure (CHF). Sympathetic stimulation may be important in maintaining the hemodynamic function in these patients, thus beta-blockade can worsen the heart failure. However, therapy with beta-blockers may be beneficial and can be administered cautiously in some CHF patients provided they are well compensated and receiving digitalis, diuretics, an ACE inhibitor, and/or nitrates. Carvedilol, specifically, is indicated for use with these agents in the treatment of mild to severe heart failure of ischemic or cardiomyopathic origin. There is also increasing evidence that the addition of a beta-blocker to standard therapy can improve morbidity and mortality in patients with advanced heart failure, although it is uncertain whether effectiveness varies significantly with the different agents. Data from one meta-analysis study suggest a greater reduction of mortality risk for nonselective beta-blockers than for beta-1 selective agents.
https://www.drugs.com/disease-interactions/metoprolol.html#CHF
Related topics
heart failure, metoprolol, congestive heart failure
Further information
- Metoprolol uses and safety info
- Metoprolol prescribing info & package insert (for Health Professionals)
- Side effects of Metoprolol (detailed)
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