Medicine - Can you take tizanidine with tramadol?

This combo is relatively safe because tramadol isn't a very sedating med. It depends on your tolerance .

Interactions between your drugs
Major
traMADol tiZANidine
Applies to: tramadol, tizanidine

Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, you should avoid driving or operating hazardous machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Other drug and disease interactions
tizanidine interacts with more than 500 other drugs and 4 diseases.
tramadol interacts with more than 500 other drugs and 9 diseases.
Drug and food interactions
Moderate
traMADol food
Applies to: tramadol

Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with traMADol. Do not use more than the recommended dose of traMADol, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.

https://www.drugs.com/interactions-check.php?interaction_list_id=183146216&drug_list=2205-0,2221-0

I suggest you contact your DR. and outweigh the benefits vs. the risks involved.