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How Long Does Invega Sustenna Stay in Your System After it Has Been Discontinued?

Responses (4)

Official Answer by 9 Jul 2013

Invega Sustenna (intramuscular injection) has a long half life range of 25 to 49 days. This is the time it takes for plasma levels to reduced by half, then in the next 25 to 49 days the plasma levels are reduced again by half and it continues.
It roughly takes around 5 to 6 half lives for a drug to be eliminated from your system to the point it is clinically no longer noticeable.

Using this calculation, as a guide, after your last dose, you could expect it to take anywhere between 150 to 300 days to be cleared from your system. Factors that cause personal variation include age, health, weight, metabolism and other medical factors.

dotwwwcom 22 Aug 2016

Hi Suzanna,
If Invega takes 25 to 49 days to reach half the plasma level then wouldn't the other half be eliminated in the next 49 days or so. Why does the half life start at 100 percent again, or 50 percent of what is left?

microcosm 8 Mar 2017

after the invega or paliperidone is is eliminated from your system how long does it take for your serotonin and dopamine levels to go back to normal? or does the dopamine serotonin antagonist effect last permanently?

Rami12 10 Nov 2017

Its been 6 and half month since my last injection and i still have side effects like tired body headache loss in concentration and pressure in my lungs can there be any type of solution to get rid of these side effects? Give me hope and God bless !!

TMWNelson 16 Jan 2018

I know you are suffering as I have too, but it will be alright. my symptoms have lessened and its been eight months and I guess it depends on how your body eliminates foreign chemicals in your body. I have hope that I will eventually be able to sleep until 7am instead of 5am and take day naps. Just hang in there!!! and don't stress.

Manoli01 4 Apr 2018

I have been feeling really I'll since being on this drug with a lot of sleeping in and no motivation and depressed all the time free discount card

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