Has anyone tried the ketamine infusions for depression. If so, would you please share your experience? I'm interested, but there is very little data online. Just a few clinical studies but no patient experiences. I'm always interested in "real" experiences to expand my knowledge.
I've had treatment resistant depression for about 5 years, since losing my 16-year job and then my father's death (I had also been caring for him). I've tried 2-3 meds in each class of anti-depressants. I also tried TMS treatment (transcranial magnetic stimulation) daily for 36 weekdays in-a-row at a local psychiatric hospital, which claims 75% improvement in depression symptoms. It helped me to get out of the house every day, but other than that, no lasting relief.
Just today, my psychiatrist mentioned Ketamine. After some discussion, he faxed an order to a compounding pharmacy which puts it in nasal spray form. He has 2 patients who are having some positive response from it, and it's one thing I haven't tried yet. He thought the cost was about $50 for 20 ml which should last months based on my dosage.
Once received, I will take one 10mg/ml spray in one nostril 3-4 times in a 36 hour period (every 8 hours or so). Then repeat that after 1 week, then repeat again after 2 more weeks, and again after 3 more weeks, then after 4 weeks... increasing the length in between dosages by a week each time. I will stop if I have any worrisome or very unpleasant side effects (which vary greatly - I'm particularly hoping for some mind-bending hallucinations).
I should receive it in the mail by the end of this week/early next week and will come back here and detail how things are going along the way. Fingers crossed!!
I am going to begin the Ketamine journey on March 20 with my first infusion. I am sorry that the nasal sprays did not work yet. The research i have done online said that the only really effective way to get the full effect was intravenously. I have had treatment resistant major depression for 15 years. Been on almost every drug out there. I was doing "ok" for me for a while when the black hole came back in January. I just can't fight it the old way anymore. I am not overly optimistic. They say the longer you have had depression and the more meds you have been on and the older you are the less likely you will respond positively to it. I am 56, and it's been since 2002.
But I am thinking that after two visits we will know if it "took" or not - as opposed to the BS we all deal with in changing these damn meds right?
Btw, check into a company called GENESIGHT! They do genetic testing from a cheek swab, and give you a detailed report on which antidepressants you are genetically not compatible with and those you might be! I just learned that I have a gene that slows down the mechanism of all SSRIs. I should not be using them to treat my depression WHICH I HAVE BEEN.
A wonderful tool for us to have finally!!
Best of luck to everybody :)
I am a bipolar 74 year old male on a 10 year bout of chronic drug resistant depression that responds to sleep deprivation. I do pretty well when I am working and sleeping no more than 4.5 hours a night. I am getting to old to do that my heart starts skipping too many beats.
I took 6 infusions on was was supposed to be on Tuesday and Friday that had a skip in in due the doctor having other plans one day. It was very successful. The Ketamine had a real added benefit in totally stopping the muscle spasms from Multiple Sclerosis. I am not sure how long it would have lasted the pain from the muscle spasms was so bad in 3 weeks that I started 100 mg dose of Ketamine as a Nasal spray for the muscle spasms and hopefully to maintain the remission of depression.
After 4 or 5 moths the nasal spray is great for muscle spasms and OK for maintenance of remission of depression. I should go back for booster infusion for depression. I think one should view the Ketamine treatment as an intervention to quickly alleviate depression that still needs treatment and realize you may have to go back for and additional infusion 2 to 4 times a year as well as continue drug treatment and other therapy.
Good luck with your depression,
Aloha, I have the treatment resistant depression and chronic pain. I am in the same situation, everybody talks about it, they may have heard how well it works, yet i have not been able to find any info from a real person. I have been strung along from my Psych, since August, for a referral, and went searching on my own, we have limited providers in HI. ECT a no go for me and TMS is contraindicated because I have ( had) manic episodes in the history. I finally found a Pain specialist who does the Ketamine infusion / and nasal spray compound ( if indictated). I go Monday Nov. 20th, 2017 for my 1st time. I am hoping for the best... ... I will post my experience when I feel I can adequately explain it. I have read its not an instant fix, but it helps you move along with things you weren't doing when in the black hole, so you feel better and can build on that.
I see you posted this in Feb. and there are comments, have you been able to try it?
I hope you are well and if you were able to try it that you would share your thoughts. (((Huggs))) and sharing is caring.
I am 61 years old, have been very depressed and anxious most of my life, but it has worsened greatly as I have gotten older. I have bipolar disorder. I have tried so many different types of drugs, with no long-term effect, that I had just about given up hope that I would ever be able to be "normal", i.e., going to grocery store, doing household chores or on worst days, getting out of bed. I am retired and feel so saddened that I can only listen to friends tell about their vacations and never go myself. I started getting ketamine infusions in March. The first 3 weeks of April were the first time in ages I hadn't woken up feeling depressed. After that, even though I continued to get infusions, I was still mildly depressed for another month, but that was so much better than before. Now, since the middle of June, my depression has not returned. I go once a week for the ketamine and Dr. Is trying to stretch to 2 wks., 3 wks. etc.
As soon as I start getting the early feelings of depression coming on, I go in right away for another treatment. I almost gave up along the way, and now I'm so glad I didn't. Be forewarned though, the treatment is like a controlled drug trip! Not some mild dissociated state with colors! Takes about an hour, recovery about 15-30 minutes. Nurse there entire time. In comfortable recliner, sleep mask, dim room, headphones with very relaxing instrumental music. Any questions, just ask! I've had quite a few now. More difficult results because of age and years of bipolar/meds. Good Luck to all who have suffered like I do!
I have been dealing with anxiety, depression, panic disorder, bipolar II, and finally Borderline Personality Disorder... a nice little combo that makes me super fun to be around. It’s been about 12 years and I am now 28. I have been on so many combinations of psych meds that I can’t even list them... anti depressants, anti anxiety, anti psychotics, mood stabilizers, anti psychotics... nothing works for more then a few months at best. I have been searching for a ketamine center since it was in trials and finally there is one by me! I started infusions last week and I have felt a lot of relief. I still feel what I am going to feel only it’s less and does not seem like such a horrible thing just like a normal thing that will pass shortly. I am so happy I started this but I also feel a bit lonely because I am the only person I know who is doing this. No one understands what the experience is like.
I have been having feelings while I am getting the infusion that are so hard to talk about because no one gets it. If anyone wants to talk via fb messenger I would love to get some insight and support and be a supporter.
I've had TRD for 25 years. For 2 years prior to trying Ketamine I had been taking Nuvigil and it not only saved my life but gave it back to me. It allowed me to feel peace of mind, contentment, pleasure and also helped me regain the passion for my husband that had been missing for a long time. There weren't enough hours in the day for all I wanted to do. My doctor slowly increased the dose over time and it always worked again with no side effects.Since I am over the limit recommended for people with Narcolepsy, no one will prescribed an inceased dosage. Been going downhill for 6 months. My doctor mentioned Ketamine. I was skeptical to say the least since meds, ECT and TMS have not worked. So I had my 4th Ketamine infusion yesterday. Seems that each treatment is more unpleasant than the previous. The progress does not compare to what Nuvigil has done for me. I only have 2 treatments left and feel that I am worse than when I started. What would you do? And why can't I continue using the one thing that works? I'm ready to give up.
- Ketamine Information for Consumers
- Ketamine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Ketamine (detailed)
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