Doxepin belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how it works, but it does affect several chemicals in the brain (including serotonin and norepinephrine). It is thought that perhaps doxepin allows these chemicals to stay in the brain longer, which can help with depression symptoms and anxiety. The medication can also block histamine receptors, making it useful as an antihistamine.
It is thought that doxepin works for insomnia treatment mostly by blocking histamine receptors in the body. Specifically, it blocks a certain type of histamine receptor known as the H1 receptor. Although drugs that block H1 receptors are used for a variety of different purposes; most of them also cause some degree of sleepiness.
Showing up on a UA would be best answered by a pharmacist, please, take care, best wishes!
- Doxepin Information for Consumers
- Doxepin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Doxepin (detailed)
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