Since the Prednisone (10mg daily) alone is not reducing the inflammation of the disease, as per my CRP blood test results, my Doctor has recommended the Methotrexate. But as I read the side effects of the drug, I am on the fence as to if I should take the MTT or deal with the pain. Has anyone had any experience with this drug? I would appreciate any comments or suggestions. Thanks
Sorry, I haven't heard of this one. I take tylenol for the pain. I am trying to take as few meds as possible because of the side effects. The best thing is to keep moving as much as possible. Good Luck.
Hi Bayross: In as few words as possible... DON"T DO IT! I don't know how old you are or what kinda' shape your in, but the people hear (your best friends , believe it"!) warned me against using metho.I heard things like "It damn near killed me"... to "i'll never take methotrexate again as long as I live."! Does it work /help? Yeah , I guess so? ? Will it kill you? Possibly"! What I know for sure is... It WILL , make you wish you were dead. Bank on the fact that you're gonna' have the disease for 2 years +/_. I caught it july 20th 2009 , on 7/20/11 it's over. Here's the deal bayross... you decide to go with "methotrexate"! good for you. You're a fool but a very brave fool & best of luck . If you decide against Metho.I will help you through "PMR"! in every and all ways, and answer any questions you may have.
What are you taking for pain Meds & how long have you had the disease ? ? Sacosam... is who I am (:->)... P.S.? what was your start dose of prednisone? 10 - 20 - 30mg /day... What does CRP stand for... Later !
Hi bavross, I have also been diagnosed with Polymyalgia Rheumatica and have been taking Prednisone and also Methotrexate for over 18 months. I was prescribed the Methotrexate as a steroid sparer and it is effective for this in reducing the dose of Prednisone as well as keeping the inflammation down. You usually only get prescribed a small dose of Methotrexate (15 mg or so) once a week and at the other end of the week folic acid to help to alleviate side effects. Because its a small dose you shouldn't suffer from serious side effects. I've been doing okay on Methotrexate and use anti nausea bands for two or three days, as well as drinking ginger tea and haven't suffered from nausea. At first I was really tired for a day or two after taking my Methotrexate, which the Rheumatology nurse recommended me to take with the largest meal of the day, in the evening, and sleeping off the worst of the side effects. This is working well for me and I hope it will for you too.
Also you are advised not to drink any alcohol as this can cause liver problems with the Methotrexate. I hope you will find the Methotrexate helpful in reducing the inflammation, with the pain reduction, ask your Rheumatologist what pain killers they recommend. Best wishes for your improving health. bacterial
I know this is a difficult disease to detect and if you were like my mother they called it stress and everything else. She was finally diagnosed with Polymyalgia. She could not live her arms up to her shoulders. The drugs she was given is prednisone and tramadol. She managed with those two drugs. However I can tell you some good news, after a few years, it went away. She has no problem except arthritis.
You ask about dealing with the pain. It sounds like you are not in much pain if you think you can deal with it. Most people know what they can tolerate. Trust me, I know this. I have chronic pain and have been treated for years. I know what things will make the pain unbearable but if I am having a good day, I can not help myself. When we go on vacation, we discuss what we are going to do and pick the sites or things we do that I want to do the most and I rest while my family does the other things.
I wish you all the best.
I was diagnosed with PMR in 2005 and have been fighting the pain ever since. I have not wanted to stay on prednisone, I hate being on it. My rhuematologist has started me on Methotrexate back in February telling me it takes several months for the medicine to take effect. I am currently on Methotrexate and Prednisone, the idea being that if the Methotrexate helps we will start cutting back on the Prednisone. All I know is that if I am not on anything, the pain is so severe I cannot even get out of a chair. Oh and by the way, I am the only male I know who has PMR... good luck!
I was diagnosed with Polymyalgia Rhuematica in March 2010 and over a year later continue in pain. I was on Predsnisone, folic acid and Methotrexate. The Dr. has been reducing the Pred from 80 mg to 3mg and the methotrexate is a 5 pills once a week. As we do not want to up the prednisone the doctor has decided to increase the methotrexate to 8 tablets once a week.
I take tylenol 3 at least once or twice a day so that I can get up and moving. At the present time I am feeling very low possibly due to the continuous pain levels. Does anyone else know how to beat this illness or at least make it liveable?
I have been taking MTT for PMR about 3 months and I have noticed an improvement in the joint pain. I'm taking a very small dosage, 2.5 mg twice a week... my pharmacist tells me there are very little side affects with a dosage this mild. hope it helps you.
Yes I was on Methotrexate for 4 months, then started having a few negative issues. My skin started breaking out in painful nodules. I started feeling Ill and having other weird pains. My doc took me off and I started Humira. Metho works for some and not for others. After stopping this medication all those symptoms did also. In order for insurance co to pay the $5000 a month for Humira you do have to try methotrexate. If your doc is prescribing this med then it means you need to be on an anti inflammatory,and prednisone is real dangerous at high doses. this is why you need another med to take w it. Most stay on smaller doses of prednisone after starting both metho and Humira and some can stop the pred all together. My opinion is anything is better than a high dose over 20mg of prednisone. 40-60mg of prednisone was making me very ill. I started to feel like I was dying. I looked like death aswell.
I was diagonosed with pmn Jan 2018 my blood sed rate was 99 .My age 77 could hardly get up had trouble walking in constant pain level 8. Was put on predsinome 20 mg per day have since tapered it over 14momths to 1mg Started taking Metroxate 10 mg 1 a week after my blood sed rate was down to 49 .IT helped with hand pain knee and back pain.after 13 months my blood sed rate is 19 normal for my age 78 .Will be completety off prednisone in 1 month.Dont know how long i will have to take metroxate for MY rheumotoligist will decide .Had no side effects from meteroxate. Hope this helps
I have had PMR and giant cell arthritis for a year. My doctor started me on 40 mg per day and it was a tremendous relief. I tapered down but relapsed in November and went back to 20 mg. All the sites I have read say to start with 20-40 mg for PMR and 40-60 mg for GCA.
I too would be highly concerned about methotrexate and suggest that you first find out how much Prednisone it takes to relieve the swelling and pain. Since you don't stay with the higher dose that long, the side effects are not as serious as methotrexate plus lower dose Prednisone.
Also I found that to have 24 hour relief I would take 1/4 to 1/3 of my dose in the evening so that I wouldn't be awake and in pain at 3 AM.
I have had PR for more than 3 years. I tried for a long time to just deal with it, but sometimes the pain was so severe in my legs I could hardly walk. Prednisone controlled my symptoms, but the long term side effects are terrible. I finally agreed to try Methotrexate, and later had to add Leflunomide. My symptoms are controlled and I am able to function normally. I haven't suffered any side effects. I've been on Methotrexate for a year. Hope this helps.
Since the original question seems to have been asked/posted in 2010... I wonder what happened with the addition of MTX? I have GCA so don't have the pain other diagnosis have, I do manage to have side effects from almost all the Rx that I am using. The MTX was added as I started my taper from prednisone as a sparring agent. Unlike the original poster, I was on a large dose of prednisone started at 80mg and then 60mg, so the taper is slow, slow, slow... even without any flares. It appears that MTX is added for different reasons for different diagnosis. I'm interested in anyone who has GCA and how their battle is going???
I've been on Methotrexate for over 10 years and have found it to be very effective for maintaining mobility with no side effects. I was given instructions by the Rheumatology Nurse about taking it once a week 2 hours after my last meal of the day and then taking 5 mg of folic acid about 4 or 5 days later. I am regularly blood tests and the results are okay. I have heard from other patients who are also getting on okay with Methotrexate.
I hope you get on okay and find a drug that is effective for you.
This is a dangerous drug..the side effects are harmful to your body and organs.
Have you tried methylprednisolone? It can be injected by your doctor and taken orally as well. Perhaps a small increase in dosage for a short time..then a taper down to the lowest you can without pain. Of course, there are side effects with prednisone..however..if you take a bone building supplement and go on a
Good diet with fresh fruits..vegs..no alcohol or sodas..you could manage better, hopefully.
MTT has more potential for side effects, I believe, than prednisone. I would ask to take far more than 10mg to see if it will drop inflammation markers before embarking on a new drug.
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