So desperate for a positive reply.
How long did it take for anxiety to diminish on Duloxetine? It has been 24 days and not much relief?
Question posted by Lee1309 on 2 days 12 hours ago
Last updated on 30 July 2025
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Answers
Dear Lee1309, I started Cymbalta (i.e., Duloxetine) about ten years ago, for both pain and anxiety. I was started on 90mg capsules, but within 3 weeks I/We cut it back to 60mgs daily. It was extremely effective for the anxiety, squelching it within a couple of weeks! Perhaps you need a higher dose? Prior to starting Duloxetine, the only concern(s) stated were discomfort upon deciding to come off it! However, I dropped 30mgs and saw no discomfort!
Good Luck!
Thanks
Hi, Lee!
Most people people begin to feel some improvements within the first 2-3 weeks but it can take 6 - 8 weeks for the drug to become fully effective. Anxiety is notoriously slow to respond to treatment so the going may take a little while.
What dose are you currently taking? I wonder if you might need a dosage adjustment? Talk to your doctor and let them know you're still not doing well.
Just to get an idea what some users have experienced:
https://www.drugs.com/comments/duloxetine/for-anxiety.html
Regards, Wildcat
Thanks again wildcat on 120mg
Lee, that's a pretty hefty dosage. Have you spoken to your doctor about it? Honestly, I don't want you you to have to consider a different medication.
Maybe the trick is a little more essence of time to see if it starts to kick in better? As I mentioned earlier anxiety disorders are slower to respond to treatment.
WC
Thanks for the reply
Been told to give it 8 weeks it's pure hell trying to find relief
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Further information
- Duloxetine uses and safety info
- Duloxetine prescribing info & package insert (for Health Professionals)
- Side effects of Duloxetine (detailed)
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