I was wondering if anyone has had a similar experience to me and can shed some light? I’m a 44yr old female, have had anxiety and depression since my early 20s. Mostly managed well with citalopram, but around mid 2022 a series of chronic stressors came to a head and I had a mental breakdown and had to give up work. I have tried all sorts of supplements, meditation and alternative therapies to no avail. In October this year, I reluctantly agreed to try a new medication. I cross tapered off citalopram at the same time as starting on Zoloft - this was for 2 weeks. I then increased my dose of Zoloft to 100mg. After another 2 weeks I upped to 150mg. After a further 4 weeks, I upped to 200mg as I have seen little improvement in my symptoms. So all in all, just over 6 weeks properly on Zoloft. I’m not seeing any improvement in anxiety, and if anything am more lethargic and less motivated to do anything. In the last week I have also had frequent diarrhea which I understand is a side effect of this medication. So two questions- how much longer should I stick this out before trying something else? And does the diarrhoea go away. I have only been on my latest dose for 5 days so wondering how long I should give it to settle. Many thanks