How long does it takes to start feeling the benefits of taking this medicine? Thank you very much!
Could anyone tell me about their experience with Zoloft?
Question posted by boating1 on 13 May 2011
Last updated on 30 December 2021 by jj1790
This question has also been asked and answered here: How long does Zoloft (sertraline) take to work?
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18 Answers
About 4 to 8 weeks and should start to get better
Thank you all for posting questions and answers, very informative. I'm trying to find out how this medicine effects older adults. Does it take longer to work its magic in senior citizens? My mother is 84 and has been taking for about a week now.
Thanks in advance for your help.
"Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve.
Sertraline (Zoloft) | NAMI: National Alliance on Mental Illness"
It took me about 2 weeks to feel like I had a grip on my anxiety
When I first started taking it I was advised by my doctors that it will take at least 3 weeks to feel the full benefits, I started feeling them after two weeks. The first week was hell but it forsure gets better friend. Tough it out you got this
It usually takes about 2 weeks to start feeling the effects but four weeks to take full effect. If you don’t feel better by 6 weeks I would advice you to let your doctor know.
I take 200mg a day, I was upped from 150mg because I was only 60% myself
I have a panic disorder
Typically 30 days u should feel Improvement if not have them up the dose or switch to another SSRI paxil saved my life and I felt relief
It took me a good 4-6 week ms before I started feeling amazing. Stick with it!
May I ask what dosage you are on?
Atross, were you at the same dosage for those 4-6 weeks ? I have been on 25mg for a month, 50mg for two, 75mg for 2 weeks and now 100mg for 3 weeks. My real question is that since they keep upping my dosage and not sticking to one dose for at least 4-6 weeks will I see benefit at 4-6 weeks at 100mg ? I went to the doctor yesterday and he told me to bump it to 125mg but I don’t think it’s had time to adjust fully since they been switching my dose so much. During the time they keep switching it is it working or when they increase the dose I’m starting at square one again ?
Hi boating1! I understand that you have questions regarding Zoloft. It normally takes a good 30 days for your blood levels to adjust to it so that you can reap the full benefits of it. Any side effects that go along with it that you may feel, are just your body's way in adjusting to it. Keep in mind, that with any antidepressant, it will take the same amount of time to adjust. I hope this works for you! Keep us posted!
Hi boating, I have been on 50mg of Zoloft for 2 years now to treat severe anxiety and panic disorder. I found that it took 30 days to reach full effect just as my gp predicted but I felt somewhat better after 2 weeks. I had previously been on Avinza(mirtazapine) for 9months which caused me to gain 10kg and stopped working unless I increased the dose every 2months. The side effects of Zoloft were mild headache and nausea but these eased after 6 weeks by which time I had also lost 15 kg (my weight has remained healthy and stable ever since) Zoloft has been so effective for me that I have overcome my panic attacks, heart attack phobia, digestive symptoms, insomnia and social anxiety and even build a successful home business. I can still feel my underlying anxiety but it doesn't interfere with my life.
I should also mention that I take Zoloft in the morning and 25mg of a betablocker, metoprolol at bedtime to prevent nocturnal heart palpitations. The only downside of Zoloft is zero libido but that's a small price to pay if your brain chemistry is making your life unbearable. Good luck, I hope this works for you.
I have been kinda going through the same thing. I started with a panic attack in early December 2018, and now when I lay down at night I feel my heart beat just enough for me to get anxious about it and it lasts all night. I just started the 25mg Zoloft and am hoping and praying this medicine will help with keeping the fixation down so I can actually sleep at night.
My gp says 50mg is the minimum effective dose. Many people need to increase it but fortunately It has been enough for me. Also I've now been able to drop the betablocker. 25mg may not be enough to see results.
Thank you so much for your positive review. I just started Zoloft 50mg last night. I had been on Prozac 20mg for three years but it seemed to stop working and when we tried to up the dose I felt HORRIBLE! I slept okay last night an today I’m a bit anxious and have stomach upset. Hopefully it goes away soon. Did you experience an increase in anxiety. If did it go away pretty soon?
With me it was with in the first week.
I have been on Zoloft for over 10 years it has worked wonders for me. No side effects that my body is aware of but I lost my pcp Dr and I've not taken it for a week and the withdrawal are terrible, crying, depressed, anxiety, and a weird tingling sensation in my head every few minutes. I'm going to my local hospital to try and get a 30 day supply tomorrow or I'm gonna stroke out. I'm 45 and going through a terrible divorce and have to have it back I love it. Thanks for reading gn
Hi I am on Zoloft. I started with 50 mg for a week, then 100 mg for another week, then I go up to 150 mg next week. I have started back on it for three weeks now. I had stopped it for a few months, but I have been feeling depressed and have anxiety. I do not notice much of a difference yet. I hope this works soon. Anyone one else that has the same or different experience.
Hi any changes on your meds since June?
Any changes on your mood Missbragg1?
Wow , yeah they say don't just stop ,taking Zoloft , I'm on 150 at nite ,going on 4 1/2 wks , still some crying and anxiety, but not as bad ,when I first started ,I take 50 mg of amitriptyline for sleep . I also have ADHD , tryna get back on Strattera . I'm go back to Mental Health too. But I hope u get your Zoloft back soon .I'm a 42 y.o. single mom , my life is very stessful . But I really hope and pray your life gets better , very soon
Hi Kay,
Thanks for the response. I am not feeling depressed anymore, however, I still feel a bit anxious. I have Xanax for that. I usually take it once a day. I also heard that CBD oil is good too and the thing is that it does not contain THC so it does not give you that high feeling. How are you feeling?
Hi Kay,
Thanks for the response. I am not feeling depressed anymore, however, I still feel a bit anxious. I have Xanax for that. I usually take it once a day. I also heard that CBD oil is good too and the thing is that it does not contain THC so it does not give you that high feeling. How are you feeling?
Hello boating1, well it has been a while since you posted your question, i just wanted to ask you how you are feeling. I am also taking zoloft, i started taking it in 2001 - 2007 and then went through a bad stage in my life and found that it was not working for me. I recently went back on it about 5 weeks ago and i am barely starting to feel better. I notice that i get anxiety and suicidal thoughts when i first got back on it, ive read that it happened to someone else as well when they increase the dose. Did this happen to you? I guess i just want to know if i am on the right medication. Thanks
Hello nenag
I start Zoloft tomorrow and was wondering how are you doing now with it. I hope well.
Dream2727
I am on a different med now. I am taking 20mg off lexapro and 50mg of seroquel. still having anxiety... Everyone is different, good luck and keep me posted.
I would suggest Hydroxyzine while first getting started on Zoloft again. I just started taking both today and the first couple hours were horrible. Suicidal thoughts rapid heart beat but after those hours everything went calm. Breathing went back to normal and energy started increasing again. As of today I'm sure ill feel a lot better as the day goes on. Ask your doctor if you can get started on a lose dose of Hydroxyzine 10 mg.
Hello bloating! I have been on Zoloft for years now. I started on 50 mg and I was titrated up to 200 mg which is the recommended max. I started feeling the effects after one week. I feel like a different person since being on Zoloft. I am calm, no anxiety anymore, no depression symptoms anymore, and things that used to bother me do not bother me anymore. In fact, nothing much bothers me. I have had insomnia but it could be a side effect of my other medication. If not, it is the Zoloft. I just do not want to change to another medication because the Zoloft is doing so well. Sometimes people take a different time frame to see any benefit from Zoloft or any other SSRI. Our chemistry make up is not the same. Give Zoloft a chance to take effect. If you have not felt any changes in your symptoms in about 3 weeks, I would report this to your doctor. Well I wish you the best! Let us know how you are doing. Sweetie Pie
Thank you sweetie pie for your response. I'm currently on 25m the only effect I notice, is I'm not crying anymore. That's about all I notice. I've tried many different medications, I hope this is the one for me.
Thank you again :)
wow im glad to see you get help with the zoloft... i got a RX for it over a week ago and havent filled it yet cause im so nervous about the side effects...
It usually takes around 4 weeks for the medicine to work. When I first started taking it I was nervous, jumpy, anxious, etc. but I managed to muscle my way through until one day I woke up and I wasn't feeling the panic/anxiety any more. I take it right before bed because it does have a tendency to make me sleepy. I am on a very low dose... only 50 mg a day.If you are having any jitters or anything when you take it you can always see if the doctor can prescribe something in addition to the Zoloft to help you stay calm until the Zoloft is able to get to the therapeutic level in your body.
I am on day 8 and my get up and go has gone I feel very out of sorts is this normal
Related topics
zoloft, depression, post traumatic stress disorder, panic disorder, premenstrual dysphoric disorder, social anxiety disorder, anxiety and stress, medicine
Further information
- Zoloft uses and safety info
- Zoloft prescribing info & package insert (for Health Professionals)
- Side effects of Zoloft (detailed)
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