I have had zopiclone before when I cannot sleep. thanks. one tablet of zopiclone 7.5 mg with 40 mg prednisone. is it safe to take it together? I have asthma exacerbation.
Hi, i typed your meds in to the interactions checker on this site and it came up as a moderate risk, i have copied and pasted the paragraph...
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of zopiclone, which is a substrate of the isoenzyme. According to product labeling, zopiclone systemic exposure (AUC) was decreased 80% by concomitant use of rifampin, a potent inducer of CYP450 3A4. A similar effect would be expected with eszopiclone, the S-enantiomer of zopiclone. Pharmacodynamically, many CYP450 3A4 inducers such as barbiturates and anticonvulsants have CNS-depressant effects, which may be additive with those of zopiclone and eszopiclone.
MANAGEMENT: Pharmacologic response to zopiclone and eszopiclone should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the hypnotic dosage adjusted if necessary.
This is a bit intense so i wanted to give u all the info without interpreting it for you. One more thing to remember is not to take these meds after a high fat/heavy meal as this will prevent them from working effectively
- Prednisone Information for Consumers
- Prednisone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Prednisone (detailed)
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