Skip to main content

Good & bad food while taking methotrexate?

4 Answers

Inactive 12 April 2013

Since starting Methotrexate injections nearly 4 hours ago I have heavy periods. I recently had an internal pelvic scan which found I have a very think womb lining (endometrium) - could this be a side effect having metrotrexate injections for crohns disease?

Votes: +0
MongaInChrist 11 Jan 2010

Yes be careful with hot spicey foods,also salty foods and acidy foods.I take Leucovorin Calcium Tablets 8 hours after taking methotrexate do to learning the hard way.Not knowing about the foods the whole inside of mouth had ulcers and took quite a few weeks to clear them up.Had to stop the methorexate for that period.Mongainchrist

Votes: +0
struman 15 Nov 2010

folic acid will also help prevent the mouth ulcers.

owensdr 18 Feb 2011

Dr. told me about the mouth ulcers so she put me on Folic Acid every day.

craighen 13 April 2013

With either the tablets and injectable forms of methotrexate, you'll also want to avoid a lot of caffeine. According to the information at, caffeine can not only decrease the effects of MTX and your dose may have to be changed as a result, but there is also the chance that too much caffeine from all sources can cause some unpleasant side effects. "Avoid drinks, foods, or diet pills that contain caffeine, such as coffee, tea, cola, and chocolate. Taking a stimulant together with methotrexate can increase your risk of unpleasant side effects This can cause headache, lightheadedness, restlessness, or insomnia." More info. available at

mitjason 11 Jan 2010

There are no known interactions with foods with the tablet form of therapy. Highly seasoned foods may increase the chances of stomach irritation. This medication may be taken with milk. Avoid alcohol completely as methotrexate and alcohol can cause irreversible damage to the liver leading to cirrhosis. Hope this helps! Good luck to you!

Votes: +0
Psyched 10 Jan 2010

You can pretty much eat whatever as long as you avoid foods with citric acid, hot foods, and rough foods.

Votes: +0
Rumana690 2 Oct 2019

Many Thanks. free discount card

Related topics

rheumatoid arthritis, methotrexate

Further information

Similar questions

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.