Can Entresto and spironolactone be taken at same time?

There is a major interaction between both medications, major meaning:

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Interactions between your drugs
Major
spironolactone valsartan
Applies to: spironolactone, Entresto (sacubitril / valsartan)

Using spironolactone together with valsartan may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while using these medications if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. It is important that you maintain adequate fluid intake during treatment with these medications, especially if you are using them for prolonged periods. In addition, talk to your doctor to see if you should limit consumption of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Source and more information:
https://www.drugs.com/interactions-check.php?drug_list=3637-17453,2105-0

If these 2 meds were prescribed by the same Dr., he/she most likely is aware of the potential interaction and has outweighed that the benefit is greater than the risk and would not put you in harms way.
Now, if they were prescribed bty 2 different Drs. and they are not aware or by 1 Dr. and he/she is also not aware that you added 1 med without clearing it with him/her, do not take them until you clarify this potential interaction.