I have been on Effexor since the beginning of January, so going on 5 and 1/2 months almost, and we have worked me up 150mg. I've been on it for about 2 weeks now at this dose. The first day I took it I was so lethargic I didn't do anything that day except lay around. At this point I had no other symptoms showed until about 2 days ago where I thought it was my restless leg acting up but it ended up being all over. My legs arms hands are all shaking and if I force myself to stop it I feel like crawling out of my skin. Is this a side effect that will go away? If not how do you deal with it? I really don't want to come off the medication because it's doing absolute wonders for my depression. Any insight would be gratefully appreciated.