I have been taking Wellbutrin XL 300mg for several years now. I am also an ultra endurance athlete (think IronMan) racing several events a year and have been doing that for some time. I effectively spend 15-20 hrs per week working out.

I have noticed that after long exercise sessions (5+hrs) which are common on the weekends for me I seem to be surly and cross for several days with highly increased anxiety levels. This is similar in many ways to how I felt before starting to take W. XL. This just started happening more frequently over the last several months as I've ramped up my exercise volumes.

Does anyone know if significant exercise has an impact of the efficacy of Wellbutrin? Is it possible I'm burning off the drug in these extended sessions?