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What is the effect of COQ10 on warfarin?

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masso 14 Feb 2016

Interactions between your selected drugs
Moderate
warfarin ubiquinone
Applies to: warfarin, CoQ10 (ubiquinone)
Ask your doctor before using warfarin together with ubiquinone. This combination may reduce the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing your prothrombin time or International Normalized Ratio (INR). It is important to tell your healthcare provider about all other medications you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.
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Other drugs that your selected drugs interact with
warfarin interacts with more than 500 other drugs.
CoQ10 (ubiquinone) interacts with 3 other drugs.
Interactions between your selected drugs and food
Moderate
warfarin food
Applies to: warfarin
Nutrition and diet can affect your treatment with warfarin. Therefore, it is important to keep your vitamin supplement and food intake steady throughout treatment. For example, increasing vitamin K levels in the body can promote clotting and reduce the effectiveness of warfarin. While there is no need to avoid products that contain vitamin K, you should maintain a consistent level of consumption of these products. Foods rich in vitamin K include beef liver, broccoli, Brussels sprouts, cabbage, collard greens, endive, kale, lettuce, mustard greens, parsley, soy beans, spinach, Swiss chard, turnip greens, watercress, and other green leafy vegetables. Moderate to high levels of vitamin K are also found in other foods such as asparagus, avocados, dill pickles, green peas, green tea, canola oil, margarine, mayonnaise, olive oil, and soybean oil. However, even foods that do not contain much vitamin K may occasionally affect the action of warfarin. There are reports of patients who experienced bleeding complications and increased INR or bleeding times after consuming large quantities of cranberry juice, mangos, or pomegranate juice. Again, you do not need to avoid these foods completely, but it may be preferable to limit their consumption, or at least maintain the same level of use while you are receiving warfarin. Talk to a healthcare provider if you are uncertain about what foods or medications you take that may interact with warfarin. It is important to tell your doctor about all medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. When warfarin is given with enteral (tube) feedings, you may interrupt the feeding for one hour before and one hour after the warfarin dose to minimize potential for interaction. Feeding formulas containing soy protein should be avoided.
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Therapeutic duplication warnings

https://www.drugs.com/interactions-check.php?drug_list=2311-0,2273-12874

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