What will break down / strip or detoxify the 3 layers of hair follicle - I need to pass a drug test?

Don't use bleach, if you can help it, that may damage the hair. There are lots of clarifying treatments for medications for the hair, putting a bc powder in Nexxus Aloe Rid treatment and using that as a 15 minute treatment is one way. The vinegar and lemon both act as acidifiers and remove meds and deposits, using powdered vitamin c and e mixed with shampoo is another way. Whatever you are trying to get out didn't show up in your post. You can leave these treatments in for 15 minutes and then use an acidifying conditioner to help close the hair down. Whether it is going to get all of it out can NOT be guaranteed but you are on the right track. There are several professional shampoos that may help, Redken hair cleansing creme shampoo, nexxus aloe rid treatment and shampoo, scruples clearifying shampoo, most professional shampoo lines have one out now. Vitamins, supplements, hard water deposits, minerals, cosmetic buildup and medication can interfere with the chemicals we use to perm and color hair. To me the Redken is the best followed by the Scruples, they have a Chelator called EDTA in them that helps remove unwanted toxin in the hair.