... often a headache. Is it safe to take a xanax about an hour after I took 100mg of tramadol? I was going to try just a half of xanax. I'm 68 yrs old and weight is 160. I've been on these meds for over a year and never took them together before because I don't like taking them. I'm afraid of side affects with any pill. Any advice on taking together would be appreciated. Thank you