I have horrible hot flashes & then freeze every hour of the day and night. I was on a estrogen supplement and did not have any hot flash, etc. But I devoloped a blood clot behind the retna of my left eye and they took me off of estrogen cold turkey. It was horrible. The doctor then put me on paxil for the same reason and gained a lot of weight. Now my doctor put me on wellbutrin because he said, it would not have as much weight gain. I have been on wellbutrin for almost 2 wks and cannot tell a difference in my hot flashes or anything yet. Will wellbutrin help with my problem and if so when should I notice a difference. Help! Donna Spencer