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Can Cymbalta be taken beyond 120mg, I would increase myself to 150mg, or 180mg. Has this been done?

6 Answers

WildcatVet 4 July 2017

***The safety of doses above 120 mg/day has not been adequately evaluated.***

As per the Information Text on and the Physician's Desk Reference.

Votes: +0
maryellenpowers2014 4 July 2017

First, let me speak in agreement with those who have suggested that you have to seek out your doctor's direction when it comes to making any changes in your medications. There is often a delicate balance between all of the meds you are on that determines how much of what he/she wants you to take and when.
Now, in terms of Cymbalta... the max dose a day is 120 mg per my very highly respected and sought after rheumatologist. I was up to 60 in the AM & 60 in the PM but have titrated my evening dose down to 30, hoping to do the same with my AM dose soon.
The side effects of over dosing can be grave. Please do not take it upon yourself to make any changes in your meds on your own.

Votes: +1
pfearn2303 4 July 2017

Well that is strange because a competent doctor would only prescribe the maximum dose of 120mg,60mg am and 60mg pm. I was prescribed 240mg in error by a doctor who is now under investigation. It has caused me some serious health issues, blackouts and vision problems.
I would certainly advise against self prescribing and talk to your doctor.
All the best, Paul.

Votes: +1
Sweetness4477 4 July 2017

First of all, never ever increase your dose on your own. Second, I was taking 60mg in morning & 60mg at night. Today my doctor increased me for the first time in a couple years. Now my dose is now 90mg in the morning & 90mg at night. Bye night I mean around 8pm. It's weird because it's almost like I feel somewhat less irritated. It's weird but if ur talking 120mg for the entire day but i don't know about in a single dose in which you have more then one a day. Third, NEVER, EVER CHANGE MEDICATION DOSES OR START/STOP ANY MEDICATION ON YOUR OWN. ALWAYS, CONSULT A PHYSICIAN!!!

Votes: +2
Inactive 26 Feb 2012

Hello crazy-one. NO. Cymbalta can cause a person blood pressure to drop. That alone should be a warning and thats at the recommended daily dose of 60mg. The ceiling dose be the person taking the drug for arthritis, depression or fibrmayalia remains at 60mg. I'd not recommend self medicating. Best of wishes,pledge

Votes: +3
Inactive 26 Feb 2012

Pledge, my friend, I know that too & my doc just took me off Lyrica & put on Savella. It Savella has a tendancy to raise BP (so watching closely) you say Cymbalta lowers it? Huh, wonder why they didn'y try that one instead. Aren't they basic in makeup? (Coffees, hot too)... Mary

Inactive 26 Feb 2012

Hi there Mary. How are you doing? Yes very true. Savella and Cymbalta are both SNRIs. A reason might be that Cymbalta, by treating Fibro and bone and joint pains thats the drug being used as an off lable use. Much as Wellbutrin, developed as an antidepressant, just as Cymbalta is, is used off label (Wellbutrin) as an drug to help people stop smoking. My son used it and it worked in his case. No longer smokes. Cymbalta is foremost an antidepressant. That it works for other conditions is a major plus to the drug. As to Cymbalta droping blood pressure, that considered a severe side effect to taking it. Not a common normal one. Iut theres a risk factor that I wouldn't want to challenge going on a higher than recommended dose by the manufacturer. Coffees great! pledge

RNDianaDisabled 4 July 2017

I never had any of the approved Fibromyalgia medicationa work. I want energy! LOL.

PurpleButterfies 26 Feb 2012

I have not heard of a prescribing dose being higher than 120mg. I don't know what side effects/overdose possibilities there are to cymbalta but I would search dosing info on this site for more info.

Votes: +0
Aaronjames45 15 June 2018

I am on Duloxetine 180mg. A few side effects. Liver and renal all good. Maybe some lightheadedness but generally happier. I would like to go to 210 but advised any benefit may not outweigh side effect

MissMary87 1 July 2018

I was on 90mg daily for a while and it wasn’t working. I was taking three 30mg capsules a day and they upped it to 120mg two months ago. I was so used to taking 3 capsules daily that I have been taking three 60mg capsules daily. free discount card

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cymbalta, depression, anxiety, pain

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