... daily. Does this make it difficult for the body to regulate body temperature and or raise body temperature?
Buprenorphine - From comparisons ive heard about Im on a particularly high dose of suboxone 24ml?
Question posted by brad hood on 2 Feb 2010
Last updated on 23 March 2012 by Morwyn
Added 3 Feb 2010:
If answer is yes -
which chemical or chemical interactions effect which organs in the process of doing so?
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3 Answers
Morwyn
23 March 2012
I take IM Buprenex and I've experienced the same side effect — I tend to feel hot and sweat a lot, even when other people think it's chilly. I've taken my temperature — I suggest you do the same just to be sure. I don't know why it makes me feel hot but my temperature is normal.
When I first started taking bupe the side effects were hard to tolerate. I was able to cut down the side effects by dividing the dose up (i.e., taking smaller amounts more times a day).
24 mg (not mL) is a very high dose of buprenorphine (Suboxone is buprenorphine + naloxone, I'm assuming the 24 mg is the bupe dose?), even for addiction. I don't think I've ever heard of anyone taking more than 16 mg. (I take a total of about 1 mg/day, but that's by intramuscular injection). How big a habit did you have? You shouldn't be taking more than you can tolerate.
mitjason
7 Feb 2010
The average dose of Suboxone in America is approximately 8mg. 24mg is a very high dose. Buprenorphine acts on the Opioid receptors in the brain which can cause the side effects that Suboxone comes with such as body temperature increase/decrease and increased sweating. According to some studies Buprenorphine is approximately 15 to 25 times more potent than morphine sulfate. So I personally believe that Buprenorphine is approximately 15 times more potent than Morphine so if you multiply your dose by 15 you are taking approximately 375mg of Morphine theoretically. The organ that makes this possible is just the brain. There's many receptors in the brain so there's not a specific spot where it causes your body to change in temperature. The highest FDA approved dose is 32mg. I've personally been on 2mg and up to 32mg. Once you reach 24mg nothing really changes in the brain if you take more so the recommended highest dose of Buprenorphine is usually 24mg and that's when you reach the ceiling effect. I hope this helps. Good luck to you!
brad hood
7 Feb 2010
I think most certainly you are wrong about the variations in the different medications mentioned. From what i have been told suboxone last's longer than morphine though is not stronger.
As for your comment about the brain's receptors being responcible for the interaction''s in body temperature; well i had assumed brain receptors control nerve conduct and do not control temperature regulation. They may or may not play a part in distinguishing what the body should do ie, identifying temp, though do not actually increase or suppress temperature.
Besides its how the body is affected that im wanting to know. Once again id have though it would be organs of the body that do this.
please tell me if im wrong
mitjason
7 Feb 2010
I wasn't comparing the length of time that Buprenorphine compares to Morphine Sulfate. I've personally worked at a Vet Clinic and was a Vet Tech. The sheet that came with the Buprenorphine from the manufacture themselves (We would use it for pain management for dogs and cats) said that it's 15 to 25 times more potent than morphine. Remember that's coming from the Manufacture not me. As far as which one last longer, of course Buprenorphine last longer! It can last up to 11 days in you system according to the manufacture. That includes Suboxone. As far as how long morphine lasts, it's a lot less of course. If you do in fact look at the dosing for Pain management 24mg of Buprenorphine is equal to approximately 375mg of Morphine sulfate per day when treating pain and pain alone. Buprenorphine will last longer than the Morphine because it has a longer half life of course.
There are situations in which an organ such as the frontal operculum, hypothalamus, brain stem, spinal cord, sympathetic chain ganglia, peripheral nerve, or eccrine sweat glands can cause sweating.
Generalized hyperhidrosis may be the consequence of autonomic dysregulation, or it may develop secondary to a metabolic disorder, febrile illness, or malignancy. In its localized form, hyperhidrosis may result from a disruption followed by abnormal regeneration of sympathetic nerves or a localized abnormality in the number or distribution of the eccrine glands, or it may be associated with other (usually vascular) abnormalities.
This condition may be idiopathic or secondary to other diseases, metabolic disorders, febrile illnesses, or MEDICATION USE.
Essential hyperhidrosis, a disorder of the eccrine sweat glands, is associated with sympathetic overactivity. It does not appear to be a generalized disorder involving vascular endothelium.
There are two groups of neurons involved in the transmission of any signal through the sympathetic system. So basically the brains Neurons are involved with sending the signals to the sympathetic system. When taking a narcotic it can cause sympathetic overactivity which results in the eccrine sweat glands to produce more sweat. I hope this is the answer you are looking for. As far as comparing Morphine with Buprenorphine for pain management look around the web. All the studies will indicate what I told you above. I hope this helps. Good luck to you. If you doubt me oh well. I'm fine with it. You can have your own opinion. Good question though! Hope to hear from you again!
mitjason
7 Feb 2010
The latter comment is for sweating. I realize you are looking for the reason why your body temperature increases and decreases. I'm researching that now and will let you know what I come up with.
mitjason
7 Feb 2010
Medications, such as antibiotics, narcotics, barbiturates, antihistamines, and many others can change your temperature. This is called drug fever. Some medications, such as antibiotics, raise the body temperature directly; others interfere with the body's ability to readjust its temperature when other factors cause the temperature to rise. Here is a website which will tell you how your body changes temperature while taking drugs. I sure hope this helps answer your question. http://www.medscape.com/viewarticle/715177_3
Good luck to you!
laurajary
3 Feb 2010
I'm not sure about other people, I'm only on 8 mg a day, which, I think is a low dose. I don't really understand what you're asking. The reason I'm answering is I have been thinking that something is wrong w/ my body's thermostat. I sweat WAY TOO MUCH. I'm hot when it's cold, cold when it's hot and some other weird things. I was wondering if that's what happening to you. Thanks. L.
brad hood
7 Feb 2010
I was asking in pursuit of an answer as to how suboxone effects the body's temperature regulation !!
Yes, with the use of suboxone i have found myself sweating more. I cannot identify with the cold when its hot bit with the axceptance of a quick cold flash that does not occur often. This does not happen in extreme heat either.
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