I was told to take it twice a day, but the larger dose before bed as it can cause drowsiness. I've found mid-day/evening and night work for me as it makes me sleepy - even counteracting my ADHA medication. (Adderall)
I always took my Lamictal in the morning because that's when I take the most of my medications. I never had any trouble with drowsiness or any other side effect for that matter. It's trial and error as each person's response to the drug will be different. Try taking it in the morning and if it makes you drowsy take it at night instead. Pharmocologically, it makes no difference in the the drug's efficacy when you take it ~ just be sure to take it at the same time each day.
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