The manufacturer doesn't seem to think its a problem. Its not in their list of medications to be careful with. The interaction checker here is not run by drugs.com and has a disclaimer if you read it you'd know that. I have checked 2 other interaction checkers and the manufacturers web site and cannot find anything about prednisone and xarelto. Xarelto alone has an increased risk of bleeding.
I take prednisone on and off all the time for my COPD. and I also takes xarelto for my afib and DVT. this combination is also given to me when I have to go to the hospital. the only reaction I have is from the prednisone which does make you nauseous. otherwise it works for me. no reactions.
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