... Does it mean that F4 is worse? Or does it go as far as F-6? And, if not is F4 the end stage of liver cirrhosis and therefore untreatable? And, does anyone know how this all fits in with being the hep c genotype of 1a or 1b? I know that Harvoni favors 1a patients for using the drug, which I am 1a. But, I read my lab work results before I started taking Harvoni and I determined that I was a F-4 ... yet, the head nurse in my doctor's office had told me over the phone that I was beginning stages of cirrhosis, F-3. I think she got it wrong or simply she was not looking at my paperwork. I don't know. It's all confusing for me
Zenn211 All the F numbers under google have to do with the drug are chemical structures it has nothing to do with the conditions of the liver took a long time to find it like the 7th page because it is from the manufacturer i could find nothing to do with rating of the liver There is a possibility that when it went on the market they changed it for lab work and such but i have never seen that done but it only has to do with one part of the drug so if that is the best i can do or find unless it is something the office us's call them again and get your answer good luck this drug has cured a lot of people Chuck1957.
Zenn211 by the way all of the different parts of the chemical structures started just like the f but they start with A1,B1 JUST like the F but went all the way up to G4 So i am sure then it changed to mouses and adsorbing of that part of the chemical. so it has to have something to do with after marketing best of luck my friend... Chuck1957
Chronic liver diseases affect the liver tissue in various ways: fibrosis and steatosis.
Any chronic attack on the liver will cause inflammation, which then leads to the formation of fibrous scar tissue in the liver, creating hepatic fibrosis. This fibrosis is therefore a scarring process that will replace damaged liver cells. The extent of this fibrosis can vary, and it is described in several stages. A normal liver is at a stage between F0 and F1. Stage F2 denotes light fibrosis, and F3 is severe fibrosis. 'Cirrhosis' is defined from stage F4, when scar tissue exists throughout the liver.
Fibrosis therefore disorganises the architecture of the liver both anatomically and functionally. When fibrosis reaches the cirrhosis stage, it is initially completely asymptomatic; this is the compensated cirrhosis stage, i.e. not complicated. It can be discovered fortuitously during scheduled examinations. The cirrhosis then decompensates, and liver complications appear.
-Portal hypertension which is secondary to liver fibrosis; this impedes venous circulation and causes the pressure in the portal vein to rise. It can promote haemorrhaging by bursting oesophageal varicose veins.
-Ascites which is the formation of a liquid effusion in the abdominal cavity, which can become infected.
-Hepatic encephalopathye which corresponds to neurological disorders by the accumulation of toxins that are not broken down by the liver.
-Primitive cancer of the liver, which is a final complication, and can also be called hepatocellular carcinoma.
Fibrosis is reversible if the cause of the disease is treated and if the lesions are not too severe. The liver can then resume a normal structure. The degree of fibrosis therefore constitutes an important prognostic parameter. The extent of the fibrosis is one factor affecting the diagnosis and decisions concerning therapy, and a criterion for tracking the progress of the illness and the effectiveness of therapy..
You as written are 1A. 1B. Which are basically the same and the most responsive to harvoni treatment with a high percent svr rate. Are you being treared with Harvoni?
F1 is lower damage of that F4 which means higher damage than f1 for instance. If i were you,i would get in person with your dr and have spell out where you are clearly. I am not sure that the google search had anything to do with drug molecules. They were most likely your damage scres. Were you a heavy drinker etc? If you are not avoiding alcohol,drugs,etc i would be watching foods erc, all i can say based on the original post, i hope you are bejng treated,and abstaibg from fat,alcohol drugs etc and sit down with your dr and find out whats going on, if you get additional info please post so we can help you get your status. Ok? Habg in there and post back
Hi zenn211, The F ratings are fibrosis ratings one being the least. It is basically a cirrhosis rating. For insurance to pay for the extremely expensive drugs most are treating F-2 or higher. Not to scare you, but with an F-4 rating I would certainly start the Harvoni. I require the Daklinza/Sovaldi meds thus I will never get to be cured. with an $85,000 price tag it"s been turned down by the insurance. Good luck with your treatment!
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