Is anyone taking Linzess 290 twice daily??

I also take LINZESS TWICE DAILY!!! (290mcg morn and nite). NOTHING else worked and my digestive doc was tireless in his efforts to get this approved!
He just recently added RELISTOR to my daily meds, and ooooohhhh WOW!!! Made all the difference in the world for me!!! I certainly understand your battle!!

Yes I'm on 2- 290gm of linzess, l also have problem with the second one, I try taking by 4pm then I'm done by bedtime. I have problem with my sinuses started shortly taking 2 of them,will be calling Doctor soon on this!

I had the same surgery as you about 13 years ago and it worked wonders until about a year ago. Gradually the constipation got worse and worse until I couldn't stand it anymore. I was almost right where I was before the surgery. The doctor who did the surgery is not the most pleasant so I decided to change and go to my mothers doctor. She put me on Linzess 290mcg once a day. She told me to take it before dinner. It worked great but now I'm finding it isn't working as well. I don't feel emptied out like I first did. The doctor did mention at my visit to try One a day and if we needed to increase it we could go to taking two a day. I haven't been back to her for my follow up yet and I don't want to increase it without seeing her. I have even thought about going back to my old doctor to find out if a second surgery would be an option. He told me if I had problems then he could go in and remove alittle more bowel. That was 13 years ago though.