Has anyone experienced extreme anger and mood swings while taking Humira?

Thank you so much everyone! I thought I was going mad. Had my first shot two weeks ago. After maybe four days I started feeling strange, slightly out of body at times, heart racing. But I was very happy, even more so than usual. Last three days I can’t keep it together. So, so angry and unhappy. Completely stressed out about basically nothing. I’m due for a shot Tuesday and will tell the doctor I’m not going to do it. Thank you again.

Had my first shot of Humira last week. Been depressed, and go from crying to throwing things. Oh what fun. I'm happy that I looked this up. I knew it wasn't me

My husband has been on Humira for two years. I am happy to find this site because I thought I was “assuming” his mood swings and memory loss. The memory loss is horrible because he will fight with you thinking he said or did something when he didn’t. On the flip side of life, if he doesn’t take the medicine he is in pain which causes depression and serious anger issues. It’s definitely a catch 22 but thank you to everyone who has responded with their issues. Happy to know I am not the only one.

I was searching online for answers when I found this message board. My husband has been on Humira for about 3 months - he now takes 1 injection every other week. He has has very bad psoriasis- completely covering his body and extremely itchy. The Humira has worked and nearly cleared up all of his skin. Lately he has been getting more and more unreasonable, angry, and irrational. His mom has dementia and I think he may be afraid of exhibiting symptoms like that, but I don’t think it’s that. He’s 53, and other wise healthy. He never smiles now and is always edgy and gets angry over nothing and I think it’s the humira. Thanks everyone for sharing your stories.

I had anxiety that progressed into severe anxiety paranoia anger and a host of emotional instability issues from using this drug.
Along with these issues I was developing extreme pain in my spine and a tingling / numbness sensation in my legs and arms.

My family and friends said that I had a complete personality change I was completely out of my mind.

I have researched this and found countless people that have had the same and very similar issues.

Things got so bad I took myself off of the drug I have never felt so out of control in my life.
Once I stopped the medication all the problems went away within a few weeks.
No more anti tnf therapy for me thanks never again.

I don't know what age group the women that answered this question fall into? Take into consideration, pre menopause or full menopause can effect moods.
Also, I have R/A and with this not only do I use Humira, I take plaquenil and methotrexate. So, if anyone needs to take other medications then this can effect moods. Not to mention the illness that we deal with can cause moods swings. I have not noticed a difference in moods since adding Humira for three years now.

I have been on Humira for over 18 years... autoimmune disease, Psoriatic Arthritis.
In the mid 1990s the insurances only covered disease modifiers for RA.
It cost about 7500.00 per month. I am currently experiencing major psych issues. I would settle for mood swings. In addition, most autoimmune diseases cause other chronic health problems. To name a few... heart (3 heart attacks), autoimmune type 2 diabetes. I now have to take 9-10 pills daily to live and my doctors have no clue how the meds should or could or would work together. The other problems... the Humira seems to gave a shelf life in your body. It stops working and you start getting certain painful problems reoccuring. If you decide to go on another drug it is possible it will not work at all, so your stuck.
I am a health care professional and I will tell you that doctors are as confused as the patients.
My big question... anyone try BCG injections... I'm scheduled... took 1 year for appt. at Mt Sinai Hospital in NYC.

yes! i am now on orencia. on humira, I didn’t realize I became so manic. My sister was bipolar but I never was but maybe I have the tendency which was triggered by humira. I got off of humira cause i kept getting sick like pneumonia and strep but now i see i was manic too... I once away 400 dollars worth of makeup to some friend (really odd of me) kept staying up all the time , was really irritable, yelled, cussed out a family member and i’m a very reserved person... I had no insight till after i got off... awful ! thank God for orencia

Yes, I have taken Humira off and on for almost 10 years for ankylosing spondylitis and I have bipolar disorder. The shot will swing me into hypomania for a week, followed by a depression. It happens every single time I take the shot. It appears as though they are studying Humira as a possible mood regulator drug (search Pub Med).

Yes! First shot! I kept miagrain and I could not sleep..I would stay awake 2 and 3 days, my chest felt like it was going to explode , raising thoughts like never before, I would get chills like I had fever then they would disappear and return back and forth, I never screamed at my children, which are adults. But it was like Satan himself , I screamed I can't take this, I don't want to live! Total freaking meltdown. My thought process was going so fast ..anger , rage, panic was incredible. Could not eat , felt sick to my stomach, cursing like a wild person and I never cuss..I'm sure there was more but ..just wow..my children and husband were scared to death! And I could see it but not stop it. Totally out of my mind exsperance I will not repeat the shot. Once I calmed down I could see the whole picture better, but I am also on other meds that I have been on long time for diabetes and nerve damage..I was wondering if it was a clash of meds or just this one alone.

I was on Humira injections for an autoimmune eye disease for over a year and after a couple of months began having severe anger and mood swings. I started doing research online and found someone who had been able to eliminate her autoimmune symptoms by going on a paleo diet which eliminates all grains and dairy. I decided I had nothing to lose and went on the paleo diet. I started going longer and longer between injections until I stopped them completely. I have not been on humira for 2 years and have been able to completely control the AI symptoms. I am not saying this will work for everyone but it did for me.

I have been on it for 8months. I was happy in the beginning that I was getting better after misdiagnosed for 17 years. I gained weight so much and started getting angry with almost everything and anyone. Most of the time depressed and sad. I am lost nowadays as the mind goes blank. Hardly slept well and always tired. I used to be so active working out and always into coaching people. Everything has gone down the drain. I started behaving so odd and not being myself. I was always happy and smiling. I started looking for an answer and saw that you guys are also going through the same. I love someone so deep and have shared this and I hope I don't lose him with Humira.. Anyone has solution?

I'm so glad that you are all out here talking about this. My 13 yr old daughter was diagnosed with severe crohns at 11 and has been taking humira for about 18months. Gradually she's become more and more depressed, hates socializing, moody, anxious leaving the house etc... she cries and gets mad over nothing. I know she's 13 and some of that is her age- but this is not my little girl... it's heart breaking. She should be happy, hanging out with her friends and enjoying her summer but she's not. Definitely have to make an appointment for some help. I really don't want her on antidepressants but if it helps her I'll try anything. Good luck to you all