My brother takes 450mg a day and gained weight. He takes it for bipolor. I have high anxity and PTSD. I take Prazosin 4mg. at night and it works wonders. While he has bipolor. Been on many things that made me worse and kinda scared to try this. My Dr told me its such a low does it wont effect my weight but I hear it will. That will made me even more sad when I have reacuring nigthmares that make me sad and hipervigalent at the same time already. Hope to hear from someone. Thanks