I've been suffering from Depression for the past 5years. I've recently started taking Prednisone for Carpal Tunnel Syndrome. Since beginning the medicine a few days ago my whole outlook on life has changed! Like this weight has lifted off my shoulders. I have my ambition back, look forward to my days to begin, and I'm not dragging through my day because of fatigue! I feel normal for the first time in years! I feel FULL of life again! Has anyone had these results??? I'm wondering about consulting with my Drs!?
Is there an anti-depressant that would have the same mood altering qualities as Prednosone?
Question posted by lab hottie1 on 17 Feb 2012
Last updated on 12 August 2021 by mcgarrymusic
I just stumbled on to this site and I’m wondering if there has been any progress by the medical community on this question. I have had the same exact experience. I’ve been on anti-depressants for many years, first Paxil then lexapro. I still have depression and more recently pretty bad anxiety. My Med doesn’t really have much effect. I also have asthma which has gotten worse over the last few years. I just came down with bronchitis which triggered my asthma so in addition to antibiotics the doc put me on prednisone 20 mg. for 5 days. The difference in my overall well being is profound. For the first time in years, I feel “normal”. I have energy! I can get things done without having to keep stopping and sitting down to rest or even nap. I’m so much clearer mentally. I didn’t even realize how much brain fog I’ve been experiencing.
It makes me sad because I feel like I’m wasting my life due to fatigue and cloudy thinking, sadness and anxiety. I’m actually dreading coming off the prednisone. Does anyone have any new info about this? I don’t want to relapse again! Ann
I have had the same exact result and after 10 years of dealing with depression and 20 different anti depressants nothing worked like prednisone.
I have had a really similar reaction. Prednisone makes me feel normal—lifts the fog of lethargy and depression. Gives me energy and confidence and I feel like a normal (non-depressed) person, which is rare. I wonder what the pattern here is. I think just saying “depression is an inflammation in the brain” is a radical oversimplification. I wonder if there could be a more benign drug that would have similar effects on brain chemistry. If you have similar effects from prednisone, please comment. It would be great if we could help doctors figure out what’s going on here. A doctor I see is interested in what might cause the radical mood change. Maybe we’re all suffering from a similar type of depression that corticosteroids somehow alleviate.
I have also noticed that when I am on prednisone, my depression is GONE!!! I have been on 3 different meds for depression since 2011. Currently 60 mgs CYMBALTA. I have chronic asthma since 1989. I finally found an awesome pulmo dr that put me on great meds (inhalers) so I have not been on steroids since last april. When I stopped using prednisone last April, by May I noticed 1 week a month all of a sudden I was so down and anxious it scared me, next month same thing, etc, etc... I did not know what the heck was going on. I got so upset I spoke to a therapist. That lasted 5 visits. On Feb 15 2019 I had a asthma attack (caught a cold from my hubby) and now i'm back ln prednisone. A few days in NO DEPRESSION, GONE!!! I have checked on line and found ADRENAL FATIGUE can be caused by yrs and yrs of prednisone use.
I am waiting for my endocrinologist to get back to me about having blood work done to check to see if that is why prednisone effects the depression/anxiety in a positive way. I have 11 of the16 symptoms for adrenal fatigue, 11!!! In the past my previous dr put me on 100mgs prednisone and taper down to 5 mgs which would take like 2 months. I did this a few times a yr since 2012.. No wonder my body loves prednisone. Prednisone, the medication I really hate/love at the same time. Asthma is scary, my chronic pain hurts like heck but depression is the worst of the three. Prednisone helps all three. Oh how I wish it didn't have so many negative side effects since it helps so much.
Prednisone targets inflammation in the body and now there is evidence that depression is caused by very low levels of chronic inflammation in the brain. No wonder Prednisone relieves depression. American sedentary lifestyle, car culture, not walking 35 minutes a day, not eating enough veggies, fast food, not having enough vitamin D and omega -3 intake , staying up late, etc all contribute to depression and this low level inflammation in the body. We need a lifestyle change if you are serious about fighting your depression. Perfect Health Diet book by Paul Jaminet has lot of knowledge on nutrition and what to eat and what not to eat, etc.
Hi, I was having the same problems with long term depression, and took Prednisone for a breathing problem, for a week. Like you ,it was like I grew another lung , I felt so much better, and no depression, with no side affects. I felt normal for the first time in years, my workouts were like a normal persons without so much struggle But now off of it has been miserable,tired all the time just miserable.Too bad they cant make a drug to deliver that kind of help. Can a person take a very small dose, say 5mg a day?
Hello. I agree with those above. The feeling you have is very temporary.
However, this is an excellent time to get back to the doc and clearly let him know that you have had this experience and would like a support medication to help you regain your sense of well being.
Because you are now at the opposite of depression and now know this is temporary, you can get on board with a good medication for the depression. Probably a different class of drugs than what you have tried before. A good Psych Doc knows what to look at. That is mostly what they do - manage medications.
The prednisone will be short term to relieve the pressure in your wrist. So don't get too worried about its effects. Hope you find some better answers. Use your energy wisely, right? Be well soon.
Be very careful with the prednisone. At first it can make you feel like you are on top of the world. But many times it can bring on some pretty bad things, such as osteoporosis, irritability, depression, anxiety and a whole host of other bad things. I was on high dose for only two weeks and did experience the manic rush of getting things done, claritiy of thoughts and so forth. One week later I was experiencing the worst anxiety I have ever felt. I am still suffering from the anxiety... enough to be hospitalizied and started on antianxiety medications. I have been off the prednisone for one month by the way. I look forward to discontinuing the psych medications and the doctors give me hope that I can quit in acouple of months. Prednisone totally messed up my adrenal corticol steroids. I will never take prednisone again. Please be careful.
Yes, prednisone is doing this because it has a tendancy to help a lot of different things like arthritis pain, etc... If you have pain problems from an injury or joint pain it will make you feel wonderful while you are on it, but unfortunately your doctor or any other will not prescribe it long term for depression. It is not good for your body system as a whole, & can break down your bones with osteoporosis too. It can stop your adrenal glands from producing cortisol whch you need to function properly. These are just two reasons they give for not using it long term. You do not want these other conditions believe me. If you suffer from depression talk to your doctor about it, or a therapist to get to the bottom of what is causing your depression. If your need meds they will be prescribed as an anti depressant.Hope this helps. & welcome to the site lob hotti 1...
- Prednisone uses and safety info
- Prednisone information for Healthcare Professionals (includes dosage details)
- Side effects of Prednisone (detailed)
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