I have been on 4mg of Zanaflex nightly for years as a preventative medication for migraines caused by TMJ and neck and shoulder soreness and stiffness. This weekend I ran out and probably cannot get more until Tuesday. I am having intense body pain (I rate it a "20"!) and nausea. No vomiting. Generally feeling weak. No fever. Could these symptoms be withdrawal?
I have to disagree. Even though Zanaflex doesnt cause dependence per say, it can cause rebound effects when one has been taking it for a long time. It should be withdrawn slowly. Here is what the FDA literature says:
If therapy needs to be discontinued, particularly in patients who have been receiving high doses for long periods, the dose should be decreased slowly to minimize the risk of withdrawal and rebound hypertension, tachycardia, and hypertonia. Patients should be advised not to stop tizanidine suddenly as rebound hypertension and tachycardia may occur. Tizanidine is closely related to clonidine, which is often abused in combination with narcotics and is known to cause symptoms of rebound upon abrupt withdrawal. Cases of rebound symptoms on sudden withdrawal of tizanidine have been reported. The case reports suggest that these patients were also misusing narcotics. Withdrawal symptoms included hypertension, tachycardia, hypertonia, tremor, and anxiety. As with clonidine, withdrawal is expected to be more likely in cases where high doses are used, especially for prolonged periods.
- Zanaflex Information for Consumers
- Zanaflex Information for Healthcare Professionals (includes dosage details)
- Side Effects of Zanaflex (detailed)
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