i am also prescribed hydrocodone,for arthritis of the spine(dish)as well as clonazepam(anxiety).
45mg mirtazapine,for sleep and depression.the problem,i am sleeping 12 to 13 hrs.to much,help?
Question posted by graddy tripp on 18 Nov 2009
Last updated on 6 January 2019
9 Answers
Liverlad79
19 Jan 2018
I’ve been on 45mg mirtazapine for 15 months and it’s the best drug I’ve taken, my moods have dramatically decreased my sleep is awesome ok I’ve put on a few pounds but I feel so good in myself these days, don’t get me wrong I have the odd down day but I deal with that.
I understand this drug will affect people differently but for me it’s a life changer
Difitzroy
14 Dec 2018
Can i ask how long did it take for u to feel happy again
Difitzroy
14 Dec 2018
Can i ask how long did it take for u to feel happy again
SallyCinnamon7
6 Jan 2019
Been on Mirtazipane for 2 months. Stuck between dosages at present as 30mg got me back to normal initially and then stopped. On 45mg but after 2 weeks really activating and feels like I’m on ecstasy or something which is a tad worrying. Still sleeping through all night even on 45mg and no tired hangover next day. The problem I still have is the anxiety as 30mg not enough and 45mg too much. Suppose just have to give it time.
SallyCinnamon7
6 Jan 2019
Been on Mirtazipane for 2 months. Stuck between dosages at present as 30mg got me back to normal initially and then stopped. On 45mg but after 2 weeks really activating and feels like I’m on ecstasy or something which is a tad worrying. Still sleeping through all night even on 45mg and no tired hangover next day. The problem I still have is the anxiety as 30mg not enough and 45mg too much. Suppose just have to give it time.
ChelleKay
16 July 2017
I take Remeron (Brand) 30mg nightly for depression and PTSD and am happy to say it has helped me tremendously. I take Dalmane for sleep b/c the Remeron does not put me to sleep. Been on it about 8 1/2 yrs and would not trade it for anything.
nc1082
16 July 2017
I take mitizpine 45mg can you take two tablets at night one dose not get me to sleep and I have not sleped properly since last week plz can you help
Inactive
31 Jan 2012
Hello graddy tripp. Not certain when you take the Clonazepam but I'd space them as far apart as possible. The mirtazapine, if possible take it as early as you can, and if you still find you're getting to much sleep, ask your doctor to cut the dose (mirtazapeine). good health and wishes to you,pledge
jdoggt
27 Jan 2010
i think that you need to cut your doses in half and see how that does but talk to your dr before you do it..also if you take the hydrocodone and klonipin at night thats why..but it would probably work if you changed up your dosing times... good luck
agoston
26 Jan 2010
Mirtazapine and other tri-cyclic antidepressants often make patients sleep for more than 12 hours. An mild/medium interaction at CYP450 between clonazepam and mirtazapine can make your sleep deeper and longer.
I suggest changing the therapy. The bezodiazepine should stay (clonazepam), but the TCI should be changed to an SSRI, for example fluvoxamine, paroxetine, sertraline, venlafaxine, ..etc. These SSRI-s are taken in the morning usually. If you have severe insomnia, a sleeping pill should be added for a shorter period (3-4 weeks). I suggest sporting also! Anyway, please consult with your doctor / pharmacist!
Best Regards,
agoston
Pharmacist
oktoday
27 Jan 2010
Hi
Agoston did you ever hear that in smaller doses they use remeron as a sleep aid as little as 7.5mg or less at bedtime and when they increase the dose up to that level of 45mg it seems to be more of an energizing agent, im curious if you ever came across that. Could they be having an opposite reaction. Remeron is an interestting antideprresant but it seems some dosage adjustments probably should be made by your doctor. Good luck
ckollars
26 Feb 2012
Oops, mirtazapine is TETRA-cyclic, not a TRI-cyclic antidepressant; it doesn't fit in the TCl family. Typically insurance puts it in a separate class ("atypical" or "miscellaneous"), because it's not part of any well-understood family of drugs, and often requires much more care than usual when substituting something a little different.
Inactive
9 May 2012
I agree. Well said.
Psychmajor
20 Nov 2009
everything you are taking has sleep properties (opiates are suposed to make you tired... its opposit for me but w/e and benzo's (not a muscle relaxent even though it does do this) are used for sleep aids very often) and the mirtazapine shouldnt make you drowsy i dont think(didnt see it on side effects list but who knows and my SSRI doesnt make me want to sleep). that seems more like a depression related issue and the only way to deal with that is a set time to sleep and wake up every day to regulate the circadian cycle
sweetpea602
2 May 2011
Hi Psychmajor,
My doc prescribed Mirtazapine for insomnia which is also a depression related issue. Mirtazaphine is an antidepressant, but used more often to help with sleep disorders. I looked it up after I was prescribed the med! Just thought you might want to know.
Beckycas
18 Nov 2009
Hi Graddy,
Been on mirtazapine off and on for several years, when I was up to 45mgs. I was feeling very hung over most of a day. So, they reduced it. I also take xanax 1.0mg a day and now they added 2 more antidepressants, celexa and Abilify. Because, I was'nt feeling really any better. And, I also take a low dose of hydrocodone every day for a shoulder screwed up by a surgeon. I would say that's not uncommon your sleeping so much, I believe it is the mirtazapine because it has a 12 hr half life. I know it's done that to me, too. So, I would certainly talk to your dr. about adjusting this med and maybe adding a different one for the reduction to keep you okay and feeling better. That's my humble opinion. I have to say though, that
mirtazapine is one of the least with side effects except it sure does put you to sleep at night. The dr. may also want to reduce your clonazepam cause it also can make you sleepy especially when taking mirtazapine. But, there are many different treatments your doctor can try that does'nt alter your clonazepam dose, I believe, if your anxious about that, I would be. So, just talk to him or her and be open to maybe a different drug to add.Hope this helps answer back if you have a question on anything I said, I'm not a doctor and no expert, just going by my own experience.
Beckycas
Beckycas
21 Nov 2009
Graddy
I have been told by 3 different doctors to take mirtazapine at night specifically cause it will definitely help put you to sleep. True, other cns depressants will also enhance the sedating affect, but I try not to take say my xanax close to the mirtazapine. And, I still think that mirtazapine with it's 12 hour half life, a pharmicist told me this, that at 45 mgs. you could be hanging over to the next day quite a bit. Once this is in my experience, I could not take that 45mg. dose, for this very reason. Just thought I would add this, because, sedation or helping you sleep is a definite effect from mirtazapine, not neccesarily a side effect either.
Beckycas
21 Nov 2009
And, I too, am on hydrocodone at a low dose, just have to be careful when taking it close to the time I take mirtazapine, too. Hope this helps more and please talk to your doctor about dosing and adjusting stuff. Tell him or her, exactly what you've said here and everything that concerns you. Hope things get more even keeled for you.
Junior1962
18 Nov 2009
Hi Graddy Tripp
Sleep problems are often part of depression, so I'm wondering whether you had them before depression or during?
Mirtazapine can act as a hypnotic (like some sleeping tabs) and clonazepam is a muscle relaxant. It may be that you are on too much medication, or that the doses are too high.
I'd go back to your Dr and tell them what you are experiencing.
Regards
Junior
Related topics
depression, sleep disorders, mirtazapine, sleep
Further information
- Mirtazapine uses and safety info
- Mirtazapine prescribing info & package insert (for Health Professionals)
- Side effects of Mirtazapine (detailed)
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