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Zomig Side Effects

Generic Name: zolmitriptan

Note: This page contains side effects data for the generic drug zolmitriptan. It is possible that some of the dosage forms included below may not apply to the brand name Zomig.

It is possible that some side effects of Zomig may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to zolmitriptan: oral tablet, oral tablet disintegrating

Other dosage forms:

As well as its needed effects, zolmitriptan (the active ingredient contained in Zomig) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking zolmitriptan, check with your doctor immediately:

More common
  • Chest pain (severe)
  • heaviness, tightness, or pressure in the chest or neck
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
Less common or rare
  • Abdominal or stomach pain (severe)
  • changes in facial skin color
  • cough or hoarseness
  • diarrhea
  • fast or irregular heartbeat
  • fever or chills
  • hives, itching, or skin rash
  • itching
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • puffiness or swelling of the eyelids or around the eyes, face, or lips
  • tightness in the chest
  • trouble breathing
  • weakness
  • Blurred vision
  • confusion
  • difficulty swallowing
  • dizziness
  • fainting
  • frequent strong or increased urge to urinate
  • headache
  • increased volume of pale, dilute urine
  • nervousness
  • pounding in the ears
  • severe numbness, especially on one side of the face or body
  • slow heartbeat
  • unusual tiredness or weakness
Incidence not known
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some zolmitriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Lack or loss of strength
  • sleepiness or unusual drowsiness
  • warm or cold sensation
Less common
  • Dizziness or lightheadedness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • sensation of spinning
  • Anxiety
  • crying
  • depersonalization
  • depression
  • dysphoria
  • euphoria
  • hyperventilation
  • irritability
  • loss of memory
  • paranoia
  • problems with memory
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the skin
  • seeing, hearing, or feeling things that are not there
  • shaking
  • trouble sleeping
  • welts

For Healthcare Professionals

Applies to zolmitriptan: nasal spray, oral tablet, oral tablet disintegrating


Cardiovascular side effects including acute myocardial infarction, arrhythmias, hypertension, and syncope have been reported infrequently. Bradycardia, extrasystoles, postural hypotension, QT prolongation, tachycardia, and thrombophlebitis have rarely been reported.[Ref]

Most of the serious cardiac events which have been reported occurred in patients with risk factors predicative of coronary artery disease.

In a study of patients with liver dysfunction, 7 out of 27 patients experienced 20 to 80 mm Hg elevations in systolic and/or diastolic blood pressure after a 10 mg dose of zolmitriptan.[Ref]

Nervous system

Nervous system side effects (11% to 21%) including dizziness (6% to 10%), somnolence (5% to 8%), and vertigo (up to 2%) have been reported. Agitation, anxiety, depression, emotional lability, and insomnia have also been reported infrequently. Akathisia, amnesia, apathy, ataxia, dystonia, euphoria, hallucinations, cerebral ischemia, hyperkinesia, hypotonia, hypertonia, and irritability have been reported rarely. Cerebral hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events including fatalities have been reported in patients treated with 5-HT1 agonists.[Ref]

Regarding the cerebrovascular events reported in patients treated with 5-HT1 agonists, in a number of cases the cerebrovascular events may have been the primary event, whose symptoms were mistaken for a migraine.[Ref]


Other side effects including pain and pressure sensations have been reported (13% to 22%). These sensations have included chest pain/tightness/pressure and/or heaviness (2% to 4%), neck/throat/jaw pain/tightness/pressure (4% to 10%), heaviness other than the chest or neck (1% to 5%), pain from a specified location (2% to 3%), and other pressure/tightness/heaviness (2%). Atypical sensations (12% to 18%) including hypoesthesia (1% to 2%), paresthesia (5% to 9%), and warm/cold sensations (5% to 7%) have been reported. Hyperesthesia has been reported infrequently. Asthenia (3% to 9%), palpitations (up to 2%), myalgia (1% to 2%), myasthenia (up to 2%) and drug-induced headache have also been reported. Otic changes including hyperacusis, ear pain, parosmia, and tinnitus have been reported infrequently.[Ref]


Gastrointestinal side effects (11% to 16%) including dry mouth (3% to 5%), dyspepsia (1% to 3%), dysphagia (up to 2%), and nausea (4% to 9%) have been reported. Increase in appetite, tongue edema, esophagitis, gastroenteritis, liver function abnormality, and thirst have been reported infrequently. Anorexia, constipation, gastritis, hematemesis, pancreatitis, melena, and ulcer have been reported rarely. Gastrointestinal ischemic events including splenic infarction, ischemic colitis, and gastrointestinal infarction or necrosis have been reported very rarely.[Ref]

Gastrointestinal ischemic events may present as bloody diarrhea or abdominal pain.[Ref]


General side effects including allergic reactions, chills, facial edema, fever, malaise, and photosensitivity have been reported infrequently.

Several adverse effects (mostly mild and transient) are dose related, including paresthesia; sensation of heaviness or tightness in the chest, neck, jaw, and throat; dizziness; somnolence; and possibly asthenia, and nausea.[Ref]


Hematologic side effects including ecchymosis have been reported infrequently. Cyanosis, thrombocytopenia, eosinophilia, and leukopenia have been reported rarely.[Ref]


Metabolic side effects including edema have been reported infrequently. Hyperglycemia, and increased alkaline phosphatase have been reported rarely.[Ref]


Musculoskeletal side effects including back pain, leg cramps, and tenosynovitis have been reported infrequently. Arthritis, tetany, myalgia, and twitching have been reported rarely.[Ref]


Respiratory side effects including bronchitis, bronchospasm, epistaxis, hiccup, laryngitis, and yawn have been reported infrequently. Apnea and voice alteration have been reported rarely.[Ref]


Hypersensitivity side effects including anaphylaxis and anaphylactoid reaction have been reported.[Ref]


Ocular side effects including dry eye and eye pain have been reported infrequently. Diplopia and lacrimation have been reported rarely.[Ref]


Genitourinary side effects including hematuria, cystitis, polyuria, urinary frequency, and urinary urgency have been reported infrequently. Miscarriage and dysmenorrhea have been reported rarely.[Ref]


Dermatologic side effects including sweating (up to 3%) have been reported. Pruritus, rash, and urticaria have been reported infrequently.[Ref]


1. "Product Information. Zomig (zolmitriptan)." Zeneca Pharmaceuticals, Wilmington, DE.

2. Alonso-Navarro H, Jimenez-Jimenez FJ "Myalgia and Cramps Associated With Zolmitriptan." Clin Neuropharmacol 28 (2005): 241-242

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.