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Telavancin Side Effects

It is possible that some side effects of telavancin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to telavancin: intravenous powder for solution

As well as its needed effects, telavancin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking telavancin, check with your doctor or nurse immediately:

Less common
  • Blood in the urine
  • change in the frequency of urination or amount of urine
  • difficulty with breathing
  • drowsiness
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • swelling of the feet or lower legs
  • weakness
Incidence not known
  • Abdominal or stomach tenderness
  • chills or fever
  • cough
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness, especially when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • hives or itching of the skin
  • nausea or vomiting
  • pain, redness, or soreness at the injection site
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash or redness of the face, base of the neck, upper body, back, and arms
  • severe abdominal or stomach cramps and pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Some telavancin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bad, unusual or unpleasant (after) taste
  • change in taste
  • diarrhea
  • foamy urine
Less common
  • Decreased appetite
  • dry, red, hot, or irritated skin
  • feeling unusually cold
  • shivering

For Healthcare Professionals

Applies to telavancin: intravenous powder for injection


Complicated skin and skin structure infections: Serious side effects were reported in 7% of telavancin-treated patients during clinical trials and most often included renal, respiratory, or cardiac events. Telavancin was discontinued due to side effects (generally nausea and rash [about 1% each]) in 8% of patients. The most common side effects reported included taste disturbance, nausea, vomiting, and foamy urine in at least 10% of patients.

Hospital-acquired and ventilator-associated bacterial pneumonia: Telavancin-treated patients with preexisting moderate/severe renal dysfunction (CrCl 50 mL/min or less) had increased mortality versus those treated with vancomycin. Serious side effects were reported in 31% of telavancin-treated patients during clinical trials. Telavancin was discontinued due to side effects (generally acute renal failure and prolonged electrocardiogram QTc interval [about 1% each]) in 8% of patients. The most common side effect was diarrhea (at least 10%).[Ref]

Nervous system

Very common (10% or more): Taste disturbance (described as a metallic or soapy taste; 33%)
Frequency not reported: Dizziness, headache[Ref]


Very common (10% or more): Nausea (up to 27%), vomiting (up to 14%)
Common (1% to 10%): Diarrhea (7%)
Frequency not reported: Clostridium difficile-associated diarrhea, abdominal pain[Ref]


Very common (10% or more): Increased serum creatinine to 1.5 times baseline (up to 16%), foamy urine (13%), renal events indicative of renal impairment (increased serum creatinine, renal impairment, renal insufficiency, and/or renal failure; up to 10%)
Common (1% to 10%): Acute renal failure (5%)
Frequency not reported: Nephrotoxicity[Ref]


Common (1% to 10%): Rigors (4%)
Frequency not reported: Infusion-related reactions, infusion site pain, infusion site erythema[Ref]


Common (1% to 10%): Decreased appetite (3%)[Ref]


Postmarketing reports: Serious hypersensitivity reactions (including anaphylactic reactions)[Ref]

Serious hypersensitivity reactions (including anaphylactic reactions) reported after first or subsequent doses of telavancin.[Ref]


Frequency not reported: QTc interval prolongation[Ref]


Frequency not reported: Pruritus, rash[Ref]


1. "Telavancin (Vibativ) for gram-positive skin infections." Med Lett Drugs Ther 52 (2010): 1-2

2. "Product Information. Vibativ (telavancin)." Theravance Inc, South San Francisco, CA.

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