Generic Name: telavancin (TEL a VAN sin)
Brand Name: Vibativ
What is telavancin?
Telavancin is an antibiotic that fights bacteria.
Telavancin is used to treat severe skin infections. Telavancin is also used to treat pneumonia caused by bacteria in a hospital setting, or pneumonia that can develop while using a ventilator (artificial breathing machine).
Telavancin may also be used for purposes not listed in this medication guide.
What is the most important information I should know about telavancin?
You may not be able to use telavancin if you are pregnant. In animal studies, telavancin caused birth defects. You may need to have a negative pregnancy test before starting this treatment.
To make sure telavancin is safe for you, tell your doctor if you have a history of kidney problems. Your kidney function will need to be checked while your are receiving this medicine.
Call your doctor at once if you have signs of kidney problems: little or no urinating, swelling in your ankles or feet, weight gain, or urine that looks foamy.
What should I discuss with my healthcare provider before receiving telavancin?
You should not use this medication if you are allergic to telavancin.
To make sure telavancin is safe for you, tell your doctor if you have:
heart disease, high blood pressure;
heart rhythm disorder, or history of Long QT syndrome; or
if you are allergic to vancomycin.
If you are able to become pregnant, you may need a pregnancy test before you start using telavancin. You are considered able to become pregnant unless you have ovarian failure, have had a tubal ligation or hysterectomy, or have been in menopause or not had a menstrual period in 2 years.
FDA pregnancy category C. You may not be able to use telavancin if you are pregnant. It is not known whether telavancin will harm an unborn baby. In animal studies, telavancin caused birth defects. Use effective birth control to prevent pregnancy during your treatment with telavancin, and tell your doctor if you become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of telavancin on the baby.
It is not known whether telavancin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is telavancin given?
Telavancin is usually given once every 24 hours for 7 to 21 days. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Telavancin is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Telavancin must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Do not use telavancin if it has particles in it. Call your pharmacist for new medication.
After mixing telavancin, store in the refrigerator and use within 72 hours.
Mixed medicine must be used within 4 hours if you keep it at room temperature.
Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Telavancin will not treat a viral infection such as the common cold or flu.
While using telavancin, your kidney function may need to be checked often.
This medication can cause unusual results with certain medical tests for bleeding or blood clotting disorders, such as "INR" or prothrombin time tests. Tell any doctor who treats you that you are using telavancin.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of telavancin.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving telavancin?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop taking this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Telavancin side effects
Some side effects may occur during the injection. Tell your caregiver right away if you feel itchy or tingly, or have a red rash on your upper body during the injection.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
diarrhea that is watery or bloody; or
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats.
Common side effects may include:
vaginal itching or discharge; or
soapy or metallic taste in your mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: telavancin side effects (in more detail)
Telavancin Dosing Information
Usual Adult Dose for Skin and Structure Infection:
10 mg/kg IV every 24 hours for 7 to 14 days
-Therapy duration should be guided by severity and site of infection and patient's clinical progress.
Approved indication: Treatment of complicated skin and skin structure infections due to susceptible isolates of Staphylococcus aureus, Streptococcus pyogenes, S agalactiae, S anginosus group, or Enterococcus faecalis
Usual Adult Dose for Nosocomial Pneumonia:
10 mg/kg IV every 24 hours for 7 to 21 days
-Telavancin should be used only when alternative therapies are not suitable.
-Therapy duration should be guided by severity of infection and patient's clinical progress.
Approved indication: Treatment of hospital-acquired and ventilator-associated bacterial pneumonia due to susceptible isolates of S aureus
What other drugs will affect telavancin?
Telavancin can harm your kidneys. This effect is increased when you also use certain other medicines, including: cidofovir, tenofovir, certain heart or blood pressure medications, or some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with telavancin, especially:
citalopram, lumefantrine, mifepristone, saquinavir; or
an antibiotic--azithromycin, clarithromycin, erythromycin, moxifloxacin, pentamidine; cancer medicine--arsenic trioxide, nilotinib, toremifene, vandetanib, vemurafenib; anti-malaria medication--chloroquine, halofantrine, lumefantrine; heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, procainamide, quinidine, sotalol; medicine to treat a psychiatric disorder--iloperidone, pimozide, thioridazine, ziprasidone, and others.
This list is not complete. Other drugs may interact with telavancin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about telavancin
- Other brands: Vibativ
Compare with other treatments for:
Where can I get more information?
- Your pharmacist can provide more information about telavancin.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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