Rasagiline Side Effects

It is possible that some side effects of rasagiline may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to rasagiline: oral tablet

As well as its needed effects, rasagiline may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking rasagiline, check with your doctor immediately:

Less common
  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • black, tarry stools
  • chest pain or discomfort
  • chest tightness or heaviness
  • chills
  • cloudy urine
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • fever
  • hives, itching, or skin rash
  • loss of appetite
  • nausea
  • painful or difficult urination
  • persistent, non-healing sore
  • pink growth on the skin
  • puffiness or swelling of the eyelids or around the eyes
  • reddish patch or irritated area
  • redness, blistering, peeling, or loosening of the skin
  • seeing, hearing, or feeling things that are not there
  • shiny bump
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sweating
  • swollen glands
  • tests that show problems with the liver
  • tightness in the chest
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness
  • white, yellow or waxy scar-like area

Some rasagiline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Acid or sour stomach
  • belching
  • difficulty with moving
  • headache
  • heartburn
  • indigestion
  • muscle pain or stiffness
  • pain in the joints
  • stomach discomfort or upset
Less common
  • Bruising
  • burning, crawling, itching, numbness, prickling, "pins and needles" or tingling feelings
  • burning, dry, or itching eyes
  • decreased interest in sexual intercourse
  • difficulty breathing
  • difficulty with moving
  • discouragement
  • excessive tearing
  • eye discharge
  • fall
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • general feeling of discomfort or illness
  • hair loss
  • inability to have or keep an erection
  • irritability
  • joint pain
  • lack of appetite
  • large, flat, blue or purplish patches in the skin
  • lightheadedness
  • loss in sexual ability, desire, drive, or performance
  • loss of interest or pleasure
  • muscle aches
  • neck pain
  • noisy breathing
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sensation of spinning
  • shivering
  • sneezing
  • stuffy nose
  • swelling or redness in the joints
  • thinning of the hair
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to rasagiline: oral tablet

Cardiovascular

Very common (10% or more): Orthostatic/postural hypotension
Common (1% to 10%): Peripheral edema, angina pectoris, hypertension, peripheral vascular disorder, first degree AV block
Uncommon (0.1% to 1%): Myocardial infarction
Postmarketing reports: Hypertensive crisis (after ingestion of unknown amounts of tyramine-rich foods)
Frequency not reported: Heart arrest, thrombosis, vascular disorder, bradycardia, vasodilatation, arrhythmia, bundle branch block, complete AV block, second degree AV block, blood pressure fluctuations, cardiovascular disorder, palpitation, ventricular arrhythmia, ventricular extrasystoles

When used as an adjunct to levodopa, the risk for developing post-treatment high blood pressure, combined with a significant increase from baseline was higher for rasagiline (2%) compared to placebo (1%).

Clinical trial data suggest that orthostatic hypotension occurs more frequently during the first 2 months of rasagiline treatment and tends to decrease over time.

Postmarketing reports of elevated blood pressure, including rare incidents of hypertensive crisis associated with the ingestion of unknown amounts of tyramine-rich foods, have been reported in patients taking recommended doses of rasagiline.

Nervous system

Very common (10% or more): Headache, dizziness
Common (1% to 10%): Paresthesia, vertigo, somnolence, carpal tunnel syndrome
Uncommon (0.1% to 1%): Cerebrovascular accident

Cases of patients treated with rasagiline and other dopaminergic medications falling asleep while engaged in activities of daily living including the operations of motor vehicles, have been reported and sometimes resulted in accidents. Some of these cases of somnolence have been reported more than 1 year after initiation of treatment.

Psychiatric

When studied as an adjunct to levodopa, the incidence of hallucinations was approximately 5% at a rasagiline dose of 0.5 mg per day, 4% at 1 mg per day, and 3% with placebo. Dose reduction or treatment discontinuation should be considered if hallucinations or psychotic-like behaviors develop.

Reduced impulse control or increased compulsive behaviors include intense urges to gamble, increased sexual urges, intense urges to spend money, and binge eating. Patients may not recognize these behaviors as abnormal. Dose reduction or treatment discontinuation should be considered if such urges develop.

Common (1% to 10%): Depression, insomnia, abnormal dreams, hallucinations, sleep disorder
Uncommon (0.1% to 1%): Confusion
Frequency not reported: Paranoid reactions, personality disorder
Postmarketing reports: Impulse control disorders, new or worsening mental status and behavioral changes, including psychotic-like behavior

Other

The postmarketing reports of serotonin syndrome, associated with agitation, confusion, rigidity, pyrexia, and myoclonus have been reported by patients treated with antidepressants/SNRI concomitantly with rasagiline.

The symptom complex resembling neuroleptic malignant syndrome, with symptoms included elevated temperature, muscular rigidity, altered consciousness, and autonomic instability, has been reported with rapid dose reduction, and withdrawal of, or changes in, drugs that increase central dopaminergic tone.

Very common (10% or more): Accidental injury, fall
Common (1% to 10%): Malaise, infection, sweating, hernia, fever, otitis media, pain
Frequency not reported: Withdrawal-emergent hyperpyrexia and confusion, resembling neuroleptic malignant syndrome, chills, dysautonomia, prolonged immobilization, pallor
Postmarketing reports: Serotonin syndrome

Dermatologic

Common (1% to 10%): Ecchymosis, rash, dermatitis, alopecia, contact dermatitis, cellulitis
Uncommon (0.1% to 1%): Vesiculobullous rash
Frequency not reported: Abscesses, gangrene, dry skin, urticaria, pruritus, skin ulcer, nail disorder, psoriasis

Oncologic

Common (1% to 10%): Melanoma, skin carcinoma, benign skin neoplasm
Frequency not reported: Breast neoplasm, cyst, Kaposi's sarcoma, bladder carcinoma

Endocrine

Frequency not reported: Goiter, inappropriate antidiuretic hormone secretion

Gastrointestinal

Very common (10% or more): Nausea
Common (1% to 10%): Dyspepsia, gastroenteritis, constipation, vomiting, dry mouth, abdominal pain, diarrhea, gingivitis, flatulence, tooth disorder
Frequency not reported: Colitis, eructation, gastritis, gastrointestinal disorder, periodontitis, halitosis, dysphagia, esophagitis, intestinal obstruction, fecal impaction, gastrointestinal hemorrhage, megacolon, mouth ulceration

Genitourinary

Common (1% to 10%): Urinary urgency, decreased libido, albuminuria, impotence
Frequency not reported: Breast pain, dysmenorrhea, prostate-specific antigen increase, dysuria, anuria, dysmenorrhea, nocturia, testis disorder, urogenital anomaly, vaginal hemorrhage

Hematologic

Common (1% to 10%): Hemorrhage, leucopenia
Uncommon (0.1% to 1%): Anemia
Frequency not reported: Eosinophilia, leukocytosis, megaloblastic anemia, thrombocytopenia

Hepatic

Frequency not reported: Abnormal liver function tests

Hypersensitivity

Common (1% to 10%): Allergy

Immunologic

Common (1% to 10%): Flu syndrome, influenza, fungal infection
Frequency not reported: Sepsis, herpes simplex

Metabolic

Common (1% to 10%): Weight loss, anorexia, decreased appetite
Frequency not reported: Hypolipemia, weight gain, gout, hyperphosphatemia, hypokalemia, increased lactic dehydrogenase

Musculoskeletal

Very common (10% or more): Dyskinesia
Common (1% to 10%): Arthralgia, arthritis, neck pain, back pain, ataxia, dystonia, myasthenia, musculoskeletal pain, balance disorder, joint disorder, tendon disorder, tenosynovitis
Frequency not reported: Tendinous contracture, myoclonus, leg cramps, bursitis, myositis, hyperkinesias, speech disorder, spinal stenosis, rhabdomyolysis following fall

Dyskinesia or exacerbation of dyskinesia has been reported when rasagiline is used as an adjunct to levodopa. A dose reduction of levodopa may mitigate this effect.

Ocular

Common (1% to 10%): Conjunctivitis, abnormal vision
Frequency not reported: Eye hemorrhage, glaucoma, nystagmus, eye disorder, blindness, diplopia, vitreous disorder

Renal

Frequency not reported: Increased blood urea nitrogen, kidney pain

Respiratory

Common (1% to 10%): Cough, upper respiratory infection, dyspnea, rhinitis, pharyngitis, asthma
Frequency not reported: Pulmonary embolus, epistaxis, pneumothorax, allergic rhinitis

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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