Rasagiline Side Effects

Brand Names: Azilect

Please note - some side effects for Rasagiline may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Rasagiline - for the Consumer

Rasagiline

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Rasagiline:

Diarrhea; dizziness; drowsiness; dry mouth; flu-like symptoms; headache; joint pain; lightheadedness; sleeplessness; stomach upset; stuffy nose.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; blood in the urine; blurred vision; changes in sexual ability or desire; chest pain; confusion; depression; enlarged pupils; fast or irregular heartbeat; fever; hallucinations; inability to sit still; numbness or tingling of the hands or feet; one-sided weakness; seizures; sensitivity to light; severe headache; skin changes; sore or stiff neck; tremor; trouble thinking or walking; unexplained nausea or vomiting; unusual sweating; vision or speech problems.

Side Effects by Body System

General

General side effects have included accidental injury (10.1%), malaise, headache, fall, fever, flu syndrome, paresthesia, vertigo, hernia, sweating, somnolence, and weight loss.

Gastrointestinal

Gastrointestinal side effects have included nausea (7.2%), vomiting (3.7% to 6.7%), dyspepsia, gastroenteritis, diarrhea, anorexia, constipation, dry mouth, abdominal pain, and gingivitis.

Dermatologic

Dermatologic side effects have included ecchymosis, rash, pruritus, skin ulcer, eczema, urticaria, exfoliative dermatitis, leukoderma, and skin carcinoma.

Hematologic

Hematologic side effects have included hemorrhage, macrocytic anemia, purpura, and thrombocythemia.

Immunologic

Immunologic side effects have included infection (14.9%).

Cardiovascular

Cardiovascular side effects have included orthotopic hypertension (6%), postural hypotension, bundle branch block, heart failure, myocardial infarct, ventricular tachycardia, arterial thrombosis, atrial arrhythmia, complete AV block, second degree AV block, bigeminy, ventricular fibrillation, and peripheral edema.

Musculoskeletal

Musculoskeletal side effects have included dyskinesia (1%), arthralgia, myasthenia, tenosynovitis, neck pain, ataxia, dystonia, bone necrosis, muscle atrophy, and arthrosis.

Respiratory

Respiratory side effects have included dyspnea, increased cough, apnea, emphysema, laryngismus, pleural effusion, pneumothorax, interstitial pneumonia, larynx edema, lung fibrosis, and rhinitis.

Psychiatric

Psychiatric side effects have included hallucinations (1% to 3%) and abnormal dreams.

Genitourinary

Genitourinary side effects have included hematuria, urinary incontinence, dysmenorrhea, dysuria, nocturia, polyuria, scrotal edema, urinary retention, vaginal hemorrhage, vaginitis, vaginal moniliasis, abnormal ejaculation, amenorrhea, epididymitis, gynecomastia, hydroureter, leukorrhea, priapism, and urinary tract infection.

Metabolic

Metabolic side effects have included weight loss (2.4% to 9.4%) and hypocalcemia.

Nervous system

Nervous system side effects have included confusion (1%), headache, abnormal gait, anxiety, hyperkinesia, hypertonia, neuropathy, tremor, agitation, aphasia, circumoral paresthesia, convulsion, delusions, dementia, dysarthria, dysautonomia, dysesthesia, emotional lability, facial paralysis, foot drop, hemiplegia, hypesthesia, incoordination, manic reaction, myoclonus, neuritis, neurosis, paranoid reaction, personality disorder, psychosis, and wrist drop. Apathy, delirium, hostility, manic depressive reaction, myelitis, neuralgia, psychotic depression and stupor have been reported rarely. Pain, back pain, dizziness, and balance difficulty have also been reported.

Oncologic

Oncologic side effects including melanoma have been reported.

Ocular

Ocular side effects including xerostomia and conjunctivitis have been reported.

Other

Other side effects have included asthenia (10.9%), accidental injury (10.1%), malaise, fall, flu syndrome, vertigo, and hernia.

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