Probenecid and Colchicine Side Effects

Generic name: colchicine / probenecid

Note: This document contains side effect information about colchicine / probenecid. Some dosage forms listed on this page may not apply to the brand name Probenecid and Colchicine.

Applies to colchicine / probenecid: oral tablet.

Get emergency medical help if you have any of these signs of an allergic reaction while taking colchicine/probenecid: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have:

• painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;

• fever, severe muscle weakness, mood changes, seizure (convulsions);

• easy bruising or bleeding, unusual weakness; or

• severe diarrhea, nausea, vomiting, or stomach pain.

Common side effects may include:

• mild nausea or stomach pain, loss of appetite;

• headache;

• dizziness;

• hair loss; or

• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to colchicine / probenecid: oral tablet.

Nervous system

Probenecid:

Frequency not reported: Headache, dizziness

Colchicine:

Frequency not reported: Peripheral neuritis^[Ref]

Gastrointestinal

Probenecid:

Frequency not reported: Nausea, vomiting, abdominal pain, anorexia, sore gums

Colchicine:

Frequency not reported: Nausea, vomiting, abdominal pain, or diarrhea (may be particularly troublesome in the presence of peptic ulcer or spastic colon)^[Ref]

Renal

Probenecid:

Frequency not reported: Nephrotic syndrome, renal colic

Colchicine:

Frequency not reported: Renal damage with hematuria and oliguria have occurred with toxic doses

Hematologic

Probenecid:

Frequency not reported: Leukopenia, aplastic anemia, hemolytic anemia (may be due to genetic deficiency of glucose 6 phosphate dehydrogenase) and anemia

Colchicine:

Frequency not reported: Thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, bone marrow failure, disseminated intravascular coagulation, aplastic anemia^[Ref]

Hepatic

Probenecid:

Frequency not reported: Hepatic necrosis.

Hypersensitivity

Probenecid:

Frequency not reported: Anaphylaxis, fever, urticaria, pruritus

Colchicine:

Frequency not reported: Urticaria^[Ref]

Dermatologic

Probenecid:

Frequency not reported: Dermatitis, alopecia, flushing

Colchicine:

Frequency not reported: Dermatitis, purpura, alopecia^[Ref]

Metabolic

Probenecid:

Frequency not reported: Precipitation of acute gouty arthritis^[Ref]

Musculoskeletal

Colchicine:

Frequency not reported: Muscular weakness^[Ref]

Genitourinary

Probenecid:

Frequency not reported: Urinary frequency, azoospermia, uric acid stones with or without hematuria, costovertebral pain^[Ref]

Other

At toxic doses, other side effects associated with colchicine have included severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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