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probenecid and colchicine (Oral route)

proe-BEN-e-sid, KOL-chi-seen

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antigout

Uses For probenecid and colchicine

Probenecid and colchicine combination is used to treat gout or gouty arthritis.

The probenecid in probenecid and colchicine helps to prevent gout attacks by removing extra uric acid from the body. The colchicine in probenecid and colchicine also helps to prevent gout attacks. Although colchicine may also be used to relieve an attack of gout, this requires more colchicine than this combination medicine contains. Probenecid and colchicine combination does not cure gout. probenecid and colchicine will help prevent gout attacks only as long as you continue to take it.

Probenecid and colchicine combination is available only with your doctor's prescription.

Before Using probenecid and colchicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For probenecid and colchicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to probenecid and colchicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this combination medicine have been done only in adult patients, and there is no specific information about its use in children.

Geriatric

Elderly people are especially sensitive to the effects of colchicine. This may increase the chance of side effects during treatment.

There is no specific information comparing use of probenecid in the elderly with use in other age groups.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Colchicine

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Probenecid

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking probenecid and colchicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using probenecid and colchicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Boceprevir
  • Clarithromycin
  • Darunavir
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Ketorolac
  • Lopinavir
  • Nefazodone
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Telithromycin
  • Tipranavir

Using probenecid and colchicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amprenavir
  • Aprepitant
  • Atorvastatin
  • Citalopram
  • Cyclosporine
  • Deferiprone
  • Diltiazem
  • Doripenem
  • Erythromycin
  • Fenofibric Acid
  • Fluconazole
  • Fosamprenavir
  • Gemfibrozil
  • Interferon Alfa-2a
  • Lomitapide
  • Lovastatin
  • Methotrexate
  • Nilotinib
  • Pegloticase
  • Pitavastatin
  • Pravastatin
  • Quinidine
  • Ranolazine
  • Reserpine
  • Simeprevir
  • Simvastatin
  • Sunitinib
  • Tacrolimus
  • Telaprevir
  • Tocophersolan
  • Verapamil
  • Zalcitabine

Using probenecid and colchicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amoxicillin
  • Aspirin
  • Bezafibrate
  • Bismuth Subsalicylate
  • Cefditoren Pivoxil
  • Cefotaxime
  • Cefpodoxime Proxetil
  • Cefprozil
  • Choline Magnesium Trisalicylate
  • Ciprofibrate
  • Ciprofloxacin
  • Clofibrate
  • Digoxin
  • Enprofylline
  • Ertapenem
  • Fenofibrate
  • Fluvastatin
  • Gatifloxacin
  • Lorazepam
  • Magnesium Salicylate
  • Meropenem
  • Norfloxacin
  • Phenprocoumon
  • Piretanide
  • Pralatrexate
  • Sodium Salicylate
  • Sodium Thiosalicylate
  • Zidovudine
  • Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using probenecid and colchicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use probenecid and colchicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of probenecid and colchicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Blood disease or
  • Cancer being treated by antineoplastics (cancer medicine) or radiation (x-rays) or
  • Heart disease (severe) or
  • Intestinal disease (severe) or
  • Kidney disease or stones (or history of) or
  • Liver disease or
  • Stomach ulcer or other stomach problems (or history of)—The chance of serious side effects may be increased

Proper Use of probenecid and colchicine

If probenecid and colchicine upsets your stomach, it may be taken with food. If this does not work, an antacid may be taken. If stomach upset (nausea, vomiting, loss of appetite, or stomach pain) continues, check with your doctor.

Take probenecid and colchicine only as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. The colchicine in this combination medicine may cause serious side effects if too much is taken.

After you begin to take probenecid and colchicine, gout attacks may continue to occur for a while. However, if you take probenecid and colchicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. After you have been taking probenecid and colchicine for several months, they may stop completely.

probenecid and colchicine will help prevent gout attacks but it will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take probenecid and colchicine also.

When you first begin taking probenecid and colchicine, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones or other kidney problems in some people. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. It is important that you follow your doctor's instructions very carefully.

Dosing

The dose of probenecid and colchicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of probenecid and colchicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For preventing gout attacks:
      • Adults—One tablet a day for one week, then one tablet twice a day. If you are still having a lot of gout attacks a month after you start taking two tablets a day, your doctor may direct you to increase the dose.
      • Children—Dose must be determined by your doctor.

Missed Dose

If you miss a dose of probenecid and colchicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using probenecid and colchicine

Your doctor should check your progress at regular visits while you are taking probenecid and colchicine.

Before you have any medical tests, tell the person in charge that you are taking probenecid and colchicine. The results of some tests may be affected by probenecid or by colchicine.

For diabetic patients:

  • The probenecid in this combination medicine may cause false test results with copper sulfate urine sugar tests (e.g., Clinitest®), but not with glucose enzymatic urine sugar tests (e.g., Clinistix®). If you have any questions about this, check with your health care professional.

Taking aspirin or other salicylates may lessen the effects of the probenecid in this combination medicine. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Also, drinking large amounts of alcoholic beverages may increase the chance of stomach problems and may increase the amount of uric acid in your blood. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while you are taking probenecid and colchicine, unless you have first checked with your doctor.

For patients taking 4 tablets or more of probenecid and colchicine a day:

  • Stop taking probenecid and colchicine immediately and check with your doctor as soon as possible if severe diarrhea, nausea or vomiting, or stomach pain occurs while you are taking probenecid and colchicine.

probenecid and colchicine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Fast or irregular breathing
  • puffiness or swelling of the eyelids or around the eyes
  • shortness of breath, troubled breathing, tightness in chest, or wheezing
  • changes in the skin color of the face occurring together with any of the other side effects listed here
  • or skin rash, hives, or itching occurring together with any of the other side effects listed here

Check with your doctor immediately if any of the following side effects occur:

Symptoms of overdose
  • Bloody urine
  • burning feeling in stomach, throat, or skin
  • convulsions (seizures)
  • diarrhea (severe or bloody)
  • fever
  • mood or mental changes
  • muscle weakness (severe)
  • nausea or vomiting (severe and continuing)
  • sudden decrease in amount of urine
  • troubled or difficult breathing

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • Difficult or painful urination
  • lower back or side pain (especially if severe or sharp)
  • skin rash, hives, or itching (occurring without other signs of an allergic reaction)
Rare
  • Black or tarry stools
  • cloudy urine
  • cough or hoarseness
  • fast or irregular breathing
  • numbness, tingling, pain, or weakness in hands or feet
  • pinpoint red spots on skin
  • sores, ulcers, or white spots on lips or in mouth
  • sore throat, fever, and chills
  • sudden decrease in the amount of urine
  • swelling of face, fingers, feet, and/or lower legs
  • swollen and/or painful glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
  • weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea (mild)
  • headache
  • loss of appetite
  • nausea or vomiting (mild)
  • stomach pain
Less common
  • Dizziness
  • flushing or redness of face (occurring without any signs of an allergic reaction)
  • frequent urge to urinate
  • sore gums
  • unusual loss of hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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