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PedvaxHIB Side Effects

Generic Name: haemophilus b conjugate (prp-t) vaccine

Note: This page contains side effects data for the generic drug haemophilus b conjugate (prp-t) vaccine. It is possible that some of the dosage forms included below may not apply to the brand name PedvaxHIB.

It is possible that some side effects of PedvaxHIB may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for solution, intramuscular powder for suspension, intramuscular solution

As well as its needed effects, haemophilus b conjugate (prp-t) vaccine (the active ingredient contained in PedvaxHIB) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking haemophilus b conjugate (prp-t) vaccine, check with your doctor or nurse immediately:

More common
  • Diarrhea
  • loss of appetite
  • vomiting
Less common
  • Earache
  • redness or swelling in the ear
  • Chest pain
  • chills
  • convulsions (seizures)
  • cough
  • fever over 102 degrees F (39 degrees C)
  • lack or loss of strength
  • shortness of breath
  • sneezing
  • sore throat
  • tightness in the chest
  • troubled breathing
  • wheezing
Incidence not known
  • Bluish lips or skin
  • dizziness
  • fast heartbeat
  • hives
  • itching (especially of the feet or hands)
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • reddening of the skin (especially around the ears)
  • skin rash
  • swelling of the eyes, face, or inside of the nose
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unusual tiredness or weakness (sudden and severe)

Some haemophilus b conjugate (prp-t) vaccine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Fever less than 102 degrees F (39 degrees C)
  • irritability
  • redness, pain, swelling, tenderness, or warm feeling at the injection site
  • reduced physical activity
  • restlessness
  • sleepiness
Less common
  • Prolonged crying lasting more than 4 hours
  • unusual high-pitched crying
Incidence not known
  • Hives or welts
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for injection


Local side effects have included local pain, redness, swelling, tenderness at the injection site.[Ref]

Nervous system

Nervous system side effects have included irritability, drowsiness, and lethargy.[Ref]


Gastrointestinal side effects have included anorexia, vomiting, and diarrhea.[Ref]


General side effects have included fever greater than 100.8°F, persistent crying, and unusual crying.[Ref]


1. "Product Information. ActHIB (haemophilus b conjugate (PRP-T) vaccine)." sanofi pasteur, Swiftwater, PA.

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