Otezla Side Effects

Generic Name: apremilast

Note: This page contains side effects data for the generic drug apremilast. It is possible that some of the dosage forms included below may not apply to the brand name Otezla.

It is possible that some side effects of Otezla may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to apremilast: oral tablet

As well as its needed effects, apremilast (the active ingredient contained in Otezla) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking apremilast, check with your doctor immediately:

Rare
  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • tiredness
  • trouble concentrating
  • trouble sleeping
Incidence not known
  • Fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • weight loss

Some apremilast side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Diarrhea
  • headache
  • nausea
Less common
  • Body aches or pain
  • chills
  • cough
  • ear congestion
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
  • upper abdominal or stomach pain
  • vomiting
Incidence not known
  • Acid or sour stomach
  • belching
  • decreased appetite
  • headache, severe and throbbing
  • heartburn
  • indigestion
  • stomach discomfort, upset, or pain
  • vomiting

For Healthcare Professionals

Applies to apremilast: oral tablet

General

The most commonly reported side effects included diarrhea, headache, and nausea.

Hypersensitivity

Frequency not reported: Hypersensitivity

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, vomiting, upper abdominal pain
Frequency not reported: Frequent bowel movement, gastroesophageal reflux disease, dyspepsia

Respiratory

Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis
Frequency not reported: Cough

Dermatologic

Frequency not reported: Rash

Metabolic

Frequency not reported: Weight decrease, decreased appetite

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Migraine

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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