Eliquis Side Effects

Generic Name: apixaban

Note: This page contains information about the side effects of apixaban. Some of the dosage forms included on this document may not apply to the brand name Eliquis.

Not all side effects for Eliquis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to apixaban: oral tablet

In addition to its needed effects, some unwanted effects may be caused by apixaban (the active ingredient contained in Eliquis). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking apixaban:

  • Blood in the eyes
  • blood in the urine
  • bloody or black, tarry stools
  • bruising or purple areas on the skin
  • confusion
  • constipation
  • coughing up blood
  • decreased alertness
  • difficulty swallowing
  • dizziness
  • fainting
  • fast heartbeat
  • headache
  • hives
  • itching
  • joint pain or swelling
  • nausea and vomiting
  • nosebleeds
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the eye
  • severe stomach pain
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

For Healthcare Professionals

Applies to apixaban: oral tablet


Uncommon (0.1% to 1%): Upper GI, lower GI, and rectal bleeding


Rare (less than 0.1%): Fatal bleeding (0.06%)


Rare (less than 0.1%): Fatal bleeding


Uncommon (0.1% to 1%): Skin rash (less than 1%), anaphylactic reactions (such as allergic edema) (less than 1%)

Nervous system

Uncommon (0.1% to 1%): Intracranial bleeding (0.33%), syncope (less than 1%)


Uncommon (0.1% to 1%): Intraocular bleed (0.21%)

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