Ingrezza Side Effects

Generic name: valbenazine

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 25, 2023.

Note: This document contains side effect information about valbenazine. Some dosage forms listed on this page may not apply to the brand name Ingrezza.

Applies to valbenazine: oral capsule.

Serious side effects of Ingrezza

Along with its needed effects, valbenazine (the active ingredient contained in Ingrezza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking valbenazine:

Less common

• Absence of or decrease in body movement
• clumsiness or unsteadiness
• dizziness
• drooling
• inability to sit still
• loss of balance control
• need to keep moving
• restlessness
• trembling and shaking of the fingers or hands
• trouble walking

Incidence not known

• Difficulty swallowing
• fainting
• high fever
• high or low blood pressure
• hives or welts, itching, or red skin rash
• increased sweating
• irregular heartbeat recurrent
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of balance control
• mask-like face
• seizures
• severe muscle stiffness
• shuffling walk
• slowed movements
• slurred speech
• stiffness of the arms and legs
• tic-like (jerky) movements of the head, face, mouth, and neck
• tiredness
• trembling and shaking of the fingers and hands
• trouble breathing
• unusually pale skin

Other side effects of Ingrezza

Some side effects of valbenazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Blurred vision
• decrease in the frequency of urination
• decrease in urine volume
• difficulty having a bowel movement (stool)
• difficulty in passing urine (dribbling)
• dry mouth
• painful urination
• sleepiness or unusual drowsiness

Less common

• Fear or nervousness
• headache
• joint pain
• muscle pain or stiffness
• nausea
• trouble sleeping
• vomiting

For Healthcare Professionals

Applies to valbenazine: oral capsule.

General

-The most common adverse reaction (5% or more and twice the rate of placebo) was somnolence.

-A total of 3% of patients discontinued treatment because of adverse reactions.^[Ref]

Nervous system

Very common (10% or more): Somnolence/fatigue/sedation (10.9%)

Common (1% to 10%): Anticholinergic effects (dry mouth, constipation, attention disturbance, blurred vision, urinary retention), balance disorders/fall/gait disturbance/dizziness, headache, akathisia/restlessness, drooling, dyskinesia,

non-akathisia extrapyramidal symptoms^[Ref]

Gastrointestinal

Common (1% to 10%): Vomiting, nausea^[Ref]

Hepatic

Common (1% to 10%): Increased alkaline phosphatase and bilirubin^[Ref]

Metabolic

Common (1% to 10%): Increased blood glucose, increased weight, increased prolactin^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia^[Ref]

Psychiatric

Common (1% to 10%): Anxiety, insomnia^[Ref]

Respiratory

Common (1% to 10%): Respiratory infections^[Ref]

Frequently asked questions

• How much does it cost and will insurance cover it?
• Which pharmacies can dispense Ingrezza?
• Does Ingrezza cause weight gain?
• How long does it take for Ingrezza to work?
• Ingrezza mechanism of action: How does it work?
• Can Ingrezza capsules be opened?
• How effective is Ingrezza?
• What condition is Ingrezza used to treat?
• Austedo vs Ingrezza: How do they compare?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer