Nexium Side Effects

Generic name: esomeprazole

Medically reviewed by Drugs.com. Last updated on Mar 19, 2024.

Note: This document provides detailed information about Nexium Side Effects associated with esomeprazole. Some dosage forms listed on this page may not apply specifically to the brand name Nexium.

Applies to esomeprazole: intravenous powder for solution.

Other dosage forms:

• oral capsule delayed release, oral packet, oral tablet delayed release
• oral capsule delayed release

Precautions

It is very important that your doctor check your or your child's progress at regular visits. Blood and urine tests may be needed to check for unwanted effects. If your or your child's condition does not improve, or if it becomes worse, check with your doctor.

Do not use this medicine if you are also using it together with rilpivirine (Edurant®) or other products containing rilpivirine (eg, Complera®, Juluca®, Odefsey®). Using these medicines together may cause serious side effects.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are receiving this medicine.

Check with your doctor right away if you have a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, nausea, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain after receiving this medicine. These could be symptoms of serious kidney problem called acute tubulointerstitial nephritis.

Serious stomach conditions may occur while taking this medicine. Check with your doctor immediately if you or your child has stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody sometimes, fever, nausea or vomiting, or unusual tiredness or weakness.

Esomeprazole injection may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of this medicine, or receive it for one year or more. Call your doctor right away if you have severe bone pain or are unable to walk or sit normally.

This medicine may cause serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

Cutaneous or systemic lupus erythematosus may occur or get worse in lupus patients receiving a PPI. Call your doctor right away if you or your child have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are using this medicine for more than 1 year, or if you are using it together with digoxin (Lanoxin®) or certain diuretics (water pills). Check with your doctor right away if you have convulsions (seizures), a fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.

This medicine may increase your risk for fundic gland polyps (abnormal tissue growth in the upper part of your stomach). This is more likely if you are receiving this medicine for more than 1 year. Talk to your doctor if you have concerns.

Make sure any doctor or dentist who treats you knows that you or your child are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, clopidogrel, nelfinavir, Plavix®, Reyataz®, Viracept®) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Common side effects of Nexium

Some side effects of esomeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Nexium

Along with its needed effects, esomeprazole (the active ingredient contained in Nexium) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking esomeprazole:

For healthcare professionals

Applies to esomeprazole: intravenous powder for injection, oral delayed release capsule, oral delayed release tablet, oral powder for reconstitution delayed release.

General adverse events

The most frequently occurring adverse reactions were headache and diarrhea.

The most frequently reported adverse reactions for patients who received triple therapy for 10 days were diarrhea, taste perversion, and abdominal pain.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 10.9%)
• Common (1% to 10%): Dizziness, somnolence, taste disturbance/perversion, vertigo
• Uncommon (0.1% to 1%): Paresthesia
• Very rare (less than 0.01%): Hepatic encephalopathy
• Frequency not reported: Hypertonia, hypoesthesia, migraine/aggravated migraine, parosmia, taste loss, tremor^[Ref]

Gastrointestinal

• Very common (10% or more): Flatulence (up to 10.3%)
• Common (1% to 10%): Abdominal pain, benign fundic gland polyps, constipation/constipation aggravated, diarrhea, dry mouth, duodenal ulcer hemorrhage, epigastric pain/aggravated epigastric pain, gastritis/aggravated gastritis, nausea/aggravated nausea, regurgitation, tooth disorder, vomiting/aggravated vomiting
• Rare (0.01% to 0.1%): Gastrointestinal (GI) candidiasis, stomatitis
• Very rare (less than 0.01%): Microscopic colitis
• Frequency not reported: Aggravated acid-related symptoms, Barrett's esophagus, benign polyps or nodules, bowel irregularity, duodenitis, dyspepsia, dysphagia, dysplasia GI, enlarged abdomen, eructation, esophagitis, esophageal disorder, esophageal stricture, esophageal ulceration, esophageal varices, frequent stools, gastric ulcer, gastroenteritis, GI hemorrhage, GI symptoms not otherwise specified, hernia, hiccup, melena, mouth disorder, mucosal discoloration, pharynx disorder, rebound hypersecretion, rectal disorder, tongue disorder, tongue edema, ulcerative stomatitis
• Postmarketing reports: Clostridium difficile associated diarrhea, fundic gland polyps, hemorrhagic necrotic gastritis (in children), pancreatitis^[Ref]

Respiratory

• Common (1% to 10%): Cough, respiratory infection, sinusitis, tachypnea (in pediatrics)
• Uncommon (0.1% to 1%): Epistaxis
• Rare (0.01% to 0.1%): Bronchospasm
• Frequency not reported: Asthma aggravated, dyspnea, larynx edema, pharyngitis, rhinitis^[Ref]

Other

• Common (1% to 10%): Accident or injury, fever/pyrexia
• Rare (0.01% to 0.1%): Malaise
• Frequency not reported: Asthenia, earache, facial edema, fatigue, leg edema, otitis media, pain, rigors, tinnitus^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus
• Uncommon (0.1% to 1%): Dermatitis, rash, urticaria
• Rare (0.01% to 0.1%): Alopecia, increased sweating/hyperhidrosis, photosensitivity
• Very rare (less than 0.01): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/ fatal TEN
• Frequency not reported: Acne, erythema, pruritus ani, rash erythematous, rash maculo-papular, skin inflammation, subacute cutaneous lupus erythematosus (SCLE)
• Postmarketing reports: Cutaneous lupus erythematosus, systemic lupus erythematosus^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension/aggravated hypertension
• Uncommon (0.1% to 1%): Peripheral edema
• Frequency not reported: Chest pain, flushing, generalized edema/swelling/inflammation, hot flush, hypertension, irregular heartbeat, phlebitis, substernal chest pain, superficial phlebitis, tachycardia, thrombophlebitis^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain
• Uncommon (0.1% to 1%): Fracture of the hip, wrist or spine
• Rare (0.01% to 0.1%): Arthralgia, myalgia
• Very rare (less than 0.01%): Muscular weakness
• Frequency not reported: Arthritis aggravated, arthropathy, cramps, fibromyalgia syndrome, hernia, hyperuricemia/increased uric acid, polymyalgia rheumatica
• Postmarketing reports: Bone fracture^[Ref]

An increased risk of hip fracture has been reported in a cohort study. The risk was significantly increased among patients prescribed long-term high PPIs.^[Ref]

Endocrine

• Common (1% to 10%): Increased serum gastrin
• Very rare (less than 0.01%): Gynecomastia
• Frequency not reported: Decreased/increased thyroxine, goiter, increased thyroid stimulating hormone^[Ref]

Local

• Common (1% to 10%): Administration/injection site reactions
• Postmarketing reports: Tissue inflammatory reaction^[Ref]

Immunologic

• Common (1% to 10%): Viral infection
• Frequency not reported: Flu-like disorder, fungal infection^[Ref]

Hepatic

• Common (1% to 10%): ALT increased
• Uncommon (0.1% to 1%): Increased liver enzymes
• Rare (0.01% to 0.1%): Hepatitis with/without jaundice
• Very rare (less than 0.01%): Hepatic failure
• Frequency not reported: Abnormal hepatic function, AST increased, bilirubinemia, increased alkaline phosphatase, increased total bilirubin^[Ref]

Ocular

• Uncommon (0.1% to 1%): Blurred vision
• Rare (0.01% to 0.1%): Visual accommodation disorder/disturbances, visual field defect
• Frequency not reported: Abnormal vision, conjunctivitis
• Postmarketing reports: Irreversible visual impairment, loss of vision^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia, irritability
• Rare (0.01% to 0.1%): Agitation, confusion, depression/aggravated depression
• Very rare (less than 0.01%): Aggression, hallucinations
• Frequency not reported: Apathy, nervousness, sleep disorder^[Ref]

Hematologic

• Rare (0.01% to 0.1%): Leukopenia, thrombocytopenia
• Very rare (less than 0.01%): Agranulocytosis, pancytopenia
• Frequency not reported: Anemia, anemia hypochromic, cervical lymphadenopathy, decreased/increased hemoglobin, decreased/increased platelets, decreased/increased white blood cell count, leukocytosis^[Ref]

Metabolic

• Rare (0.01% to 0.1%): Hyponatremia
• Very rare (less than 0.01%): Hypomagnesemia with or without hypocalcemia and/or hypokalemia, severe hypomagnesemia
• Frequency not reported: Anorexia, decreased/increased potassium, increased sodium, increased appetite, vitamin B12 (cyanocobalamin) deficiency, thirst, weight decrease/increase^[Ref]

Hypersensitivity

• Rare (0.01% to 0.1%): Anaphylactic reaction/shock, angioedema, hypersensitivity reactions
• Frequency not reported: Allergic reaction^[Ref]

Renal

• Very rare (less than 0.01%): Interstitial nephritis with/without renal failure
• Frequency not reported: Glycosuria
• Postmarketing reports: Acute interstitial nephritis, impaired renal function, increased creatinine, nephrosis^[Ref]

Genitourinary

• Frequency not reported: Abnormal urine, albuminuria, cystitis, dysmenorrhea, dysuria, genital moniliasis, hematuria, impotence, menstrual disorder, micturition frequency, moniliasis, polyuria, vaginitis^[Ref]

See also:

Frequently asked questions

• Nexium vs Prilosec: What's the difference between them?

Further information

Nexium side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer