Nesiritide Side Effects

It is possible that some side effects of nesiritide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to nesiritide: intravenous powder for solution

As well as its needed effects, nesiritide may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking nesiritide, check with your doctor immediately:

More common
  • Low blood pressure
Less common
  • Bluish lips or skin
  • chest pain, tightness, or discomfort
  • cool, clammy skin
  • difficulty in breathing or shortness of breath
  • dizziness
  • fainting
  • lightheadedness
  • fast, slow, or irregular heartbeat
  • unusual tiredness or weakness

Some nesiritide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Headache
Less common
  • Abdominal or stomach pain
  • anxiety
  • back pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings on the skin
  • change in vision
  • confusion
  • coughing or spitting up blood
  • fever
  • increased cough
  • itching skin
  • leg cramps
  • nausea
  • pain or irritation at the injection site
  • pale skin, unusual bleeding or bruising
  • rash
  • sleepiness or unusual drowsiness
  • sleeplessness
  • sweating
  • trembling or shakiness
  • vomiting

For Healthcare Professionals

Applies to nesiritide: intravenous powder for injection

Cardiovascular

Cardiovascular side effects have included hypotension (11% to 35%), ventricular tachycardia (3% to 10%), ventricular extrasystoles (3% to 4%), angina pectoris (2% to 6%), and bradycardia (1% to 5%). Other side effects occurring in at least 1% of patients have included tachycardia, atrial fibrillation, and AV node conduction abnormalities.

The mean duration of symptomatic hypotension was 2.2 hours with nesiritide, compared to 0.7 hours with nitroglycerin.

Nesiritide was associated with a lower incidence of severe ventricular arrhythmias than dobutamine: sustained ventricular tachycardia (1% vs 7%), nonsustained ventricular tachycardia (11% vs 17%), cardiac arrest (0 vs 5%).

Nervous system

Nervous system side effects have included headache (up to 4.2%), insomnia (2% to 6%), dizziness (3% to 6%), and anxiety (2% to 3%). Other side effects occurring in at least 1% of patients have included confusion, paresthesia, somnolence, tremor, and fever.

Gastrointestinal

Gastrointestinal side effects have included dry mouth (up to 20.1%), constipation (up to 9.6%), upper abdominal pain (up to 1.5%), constipation (up to 1.4%), dyspepsia (up to 1.2%), and flatulence (up to 1.2%).

Local

Local reactions reported in at least 1% of patients have included catheter pain and injection site reactions.

Respiratory

Respiratory side effects reported in at least 1% of patients have included increased cough and apnea.

Renal

Renal side effects reported have included increases in serum creatinine of greater than 0.5 mg/dL above baseline (17% in patients receiving 0.015 mcg/kg/min, 19% in patients receiving 0.03 mcg/kg/min, 28% in patients receiving a 2 mcg/kg bolus followed by 0.020 mcg/kg/min).

Other

Other side effects have included anticholinergic central nervous system (CNS) effects including dizziness, confusion, hallucinations and somnolence. Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered.

Ocular

Ocular side effects have included amblyopia (up to 1%) and dry eyes (up to 1.2%).

Dermatologic

Dermatologic side effects have included pruritus and rash in at least 1% of patients. Angioedema of the face, lips, tongue, and/or larynx has been reported postmarketing.

Endocrine

Endocrine side effects have included sweating in at least 1% of patients.

Musculoskeletal

Musculoskeletal side effects have included back pain (1% to 4%) and leg cramps (at least 1%).

Hematologic

Hematologic side effects have included anemia in at least 1% of patients.

Metabolic

Metabolic side effects have included hypokalemia (3%) and hypomagnesemia (1% to 3%) in a trial with 103 CHF patients.

Hypersensitivity

Hypersensitivity side effects including postmarketing reports of hypersensitivity reactions have been reported.

Genitourinary

Genitourinary side effects have included urinary retention (up to 1.2%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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