Levomilnacipran Side Effects

It is possible that some side effects of levomilnacipran may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to levomilnacipran: oral capsule extended release

Along with its needed effects, levomilnacipran may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:

More common
  • Difficult urination
  • fast, pounding, or irregular heartbeat or pulse
Less common
  • Anxiety
  • arm, back, or jaw pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • cloudy urine
  • confusion
  • decrease in the frequency of urination
  • difficulty in passing urine (dribbling)
  • difficulty in speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drooling
  • dry mouth
  • fainting
  • headache
  • irritability
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful urination
  • pounding in the ears
  • rapid or irregular heartbeat
  • restlessness
  • shaking
  • shortness of breath
  • shuffling walk
  • slow heartbeat
  • stiffness of the limbs
  • sweating
  • trouble sleeping
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual tiredness or weakness

Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • increased sweating
  • loss in sexual ability, desire, drive, or performance
  • vomiting
Less common
  • Abdominal or stomach pain
  • bloated or full feeling
  • decreased appetite
  • dry eyes
  • dry skin
  • feeling of warmth
  • headache, severe and throbbing
  • hives or welts
  • itching
  • passing gas
  • rash
  • red eye
  • red face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • thirst
  • yawning

For Healthcare Professionals

Applies to levomilnacipran: oral capsule extended release


Very common (10% or more): Tachycardia (17%)
Common (1% to 10%): Heart rate increased (6%), palpitations (5%), hypertension (3%), hypotension (3%)
Less than 2%: Angina pectoris, supraventricular and ventricular extra systoles, chest pain


Common (1% to 10%): Hyperhidrosis (9%), rash (2%)
Less than 2%: Dry skin, pruritus, urticaria


Very common (10% or more): Nausea (17%)
Common (1% to 10%): Constipation (9%), vomiting (5%)
Less than 2%: Abdominal pain, flatulence


Common (1% to 10%): Erectile dysfunction (6%), ejaculation disorder (5%), testicular pain (4%), urinary hesitation (4%)
Less than 2%: Pollakiuria, hematuria, proteinuria
Frequency not reported: Urinary hesitation or retention


Less than 2%: blood cholesterol increased
Frequency not reported: Abnormal bleeding, hyponatremia


Less than 2%: Abnormal liver function test


Frequency not reported: Hypersensitivity


Common (1% to 10%): Decreased appetite (3%)
Less than 2%: Thirst

Nervous system

Common (1% to 10%): Hot flush (3%)
Less than 2%: Migraine, paresthesia, syncope, extrapyramidal disorder
Frequency not reported: Seizure, discontinuation syndrome, suicidal thoughts and behaviors in adolescents and young adults, serotonin syndrome


Less than 2%: Dry eye, blurred vision, conjunctival hemorrhage
Frequency not reported: Narrow-angle glaucoma


Less than 2%: Agitation, anger, bruxism, panic attack, tension, aggression
Frequency not reported: Activation of mania/hypomania


Less than 2%: Yawning

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