Exforge Side Effects

Generic Name: amlodipine / valsartan

Note: This document contains side effect information about amlodipine / valsartan. Some of the dosage forms listed on this page may not apply to the brand name Exforge.

Some side effects of Exforge may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to amlodipine / valsartan: oral tablet

Along with its needed effects, amlodipine / valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / valsartan:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
Less common
  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fever
  • headache
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness
Rare
  • Ankle, knee, or great toe joint pain
  • bloody or cloudy urine
  • blurred or loss of vision
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • cold sweats
  • confusion
  • congestion
  • cough producing mucus
  • diarrhea
  • difficult, burning, or painful urination
  • disturbed color perception
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • flushed, dry skin
  • heart murmur
  • hives
  • hoarseness
  • indigestion
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea
  • pain in the lower back, bottom, or hips
  • pain in the upper leg
  • pain or tenderness around the eyes and cheekbones
  • rash
  • redness of the skin
  • stomach cramps, tenderness, or pain
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness of the chest
  • trouble with swallowing
  • troubled breathing
  • vomiting
  • watery or bloody diarrhea
  • weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking amlodipine / valsartan:

Symptoms of overdose
  • Chest discomfort
  • cold, clammy skin
  • fast, weak pulse
  • flushing
  • lightheadedness or fainting
  • slow heartbeat

Some side effects of amlodipine / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare
  • Acid or sour stomach
  • back pain
  • belching
  • bone pain
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • fear or nervousness
  • feeling sad or empty
  • full or bloated feeling
  • hearing loss
  • heartburn
  • inability to have or keep an erection
  • increased sensitivity to sunlight
  • irritability
  • itching, pain, redness, or swelling of the eye or eyelid
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • loss of interest or pleasure
  • muscle aching or cramping
  • pain in the arms or legs
  • passing gas
  • pressure in the stomach
  • redness in the joints
  • redness of the skin
  • sensation of spinning
  • skin rash, encrusted, scaly, and oozing
  • sleepiness or unusual drowsiness
  • swelling of the abdominal or stomach area
  • tiredness
  • toothache
  • trouble concentrating
  • unable to sleep
  • unusually warm skin
  • watering of the eyes

For Healthcare Professionals

Applies to amlodipine / valsartan: oral tablet

Cardiovascular

Cardiovascular side effects for amlodipine-valsartan in relation to placebo therapy have included peripheral edema (5.4% vs 3.0%). Additional cardiovascular side effects reported include orthostatic events (orthostatic hypotension and postural dizziness) in less than 1% of patients, palpitations, bradycardia, vasculitis, syncope, arrhythmia, heart murmur, and tachycardia.

The incidence of peripheral edema is lower with the combination of amlodipine-valsartan than with amlodipine alone.

Dermatologic

Dermatologic side effects including flushing, pruritus, rash, hyperhidrosis, exanthema, eczema, alopecia, and erythema multiforme have been reported.

Endocrine

Endocrine side effects have included diabetes mellitus.

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, constipation, dyspepsia, abdominal pain, anorexia, dysphagia, pancreatitis, gastritis, vomiting, abdominal discomfort and distention, gastroenteritis, dry mouth, flatulence, tonsillitis, and colitis.

Genitourinary

Genitourinary side effects have included hematuria, pollakiuria, micturation frequency, nocturia, impotence, erectile dysfunction, and cystitis.

Hematologic

Hematologic side effects have included leucopenia, neutropenia, purpura, and thrombocytopenia.

Hepatic

Hepatic side effects including elevated liver enzymes have been reported in patients treated with amlodipine-valsartan.

Metabolic

Metabolic side effects have included hyperkalemia, gout, hyperglycemia, weight gain, weight loss, and hypercholesterolemia.

Musculoskeletal

Musculoskeletal side effects including arthralgia, back pain, muscle spasms, pain in extremities, myalgia, osteoarthritis, joint swelling, muscle cramps, and musculoskeletal chest pain have been reported.

Nervous system

Nervous system side effects for amlodipine-valsartan in relation to placebo therapy have included dizziness (2.1% vs 0.9%). Other nervous system side effects including headache (4.3%), insomnia, peripheral neuropathy, tremor, sciatica, paresthesia, cerviocobrachial syndrome, carpal tunnel syndrome, hypoesthesia, and somnolence have been reported.

Ocular

Ocular side effects including abnormal vision, conjunctivitis, diplopia, and eye pain have been reported.

Other

Other side effects have included ear pain, tinnitus, fatigue, asthenia, malaise, lymphadenopathy, fever, edema, and chest pain.

Psychiatric

Psychiatric side effects including anxiety, nervousness, abnormal dreams, depersonalization, and depression have been reported.

Renal

Renal side effects including nephrolithiasis, and increases in serum creatinine and blood urea nitrogen (BUN) have been reported.

In hypertensive patients, greater than 50% increases in serum creatinine were reported in 0.4% of patients given amlodipine-valsartan compared with 0.6% in those given placebo. In heart failure patients, greater than 50% increases in creatinine were reported in 3.9% of valsartan-treated patients compared with 0.9% of placebo-treated patients. In postmyocardial infarction patients, doubling of serum creatinine were reported in 4.2% of patients given valsartan and in 3.4% of captopril-treated patients.

In hypertensive patients, greater than 50% increases in BUN were reported in 5.5% of amlodipine-valsartan treated patients compared with 4.7% of placebo-treated patients. In heart failure patients, greater than 50% increases in BUN were reported in 16.6% of patients given valsartan compared with 6.3% of patients given placebo.

Respiratory

Respiratory side effects for amlodipine-valsartan in relation to placebo therapy have included nasopharyngitis (4.3% vs 1.8%) and upper respiratory tract infection (2.9% vs 2.1%). Other respiratory side effects have included cough, dyspnea, nasopharyngitis, sinusitis, bronchitis, pharyngitis, pharyngolaryngeal pain, sinus/nasal congestion, dyspnea, epistaxis, pneumonia, and dysphonia.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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