Estradiol / levonorgestrel Side Effects
Some side effects of estradiol / levonorgestrel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to estradiol / levonorgestrel: weekly patch
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking estradiol / levonorgestrel:
Headache; irregular vaginal bleeding or spotting; mild breast pain; mild hair loss; nausea; stomach cramps or bloating; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast lumps; breast pain; calf pain or tenderness; changes in vision or speech (eg, change in contact lens fit, loss of vision); chest pain; coughing of blood; dizziness; fainting; mental or mood changes (eg, severe depression, memory loss); pain, swelling, or tenderness in the stomach; severe headache or vomiting; severe, persistent, or unusual vaginal bleeding; slurred speech; sudden shortness of breath; swelling of hands or feet; unusual vaginal discharge, itching, or odor; weakness or numbness of an arm or leg; yellowing of the skin or eyes.
For Healthcare Professionals
Applies to estradiol / levonorgestrel: transdermal film extended release
Cardiovascular side effects have included myocardial infarction and stroke as well as venous thrombosis and pulmonary embolism. Hypertension has been reported in 3.3 % of patients in one study.
Dermatologic side effects have included application site reactions (40.6%) and rash (2.4%).
Gastrointestinal side effects have included flatulence (3.8%).
Genitourinary side effects have included urinary tract infection (3.3%), vaginal bleeding (36.8%), breast pain (18.9%), and vaginitis (1.9%).
Musculoskeletal side effects have included back pain (6.1%) and arthralgia (4.2%).
Oncologic side effects have included endometrial and breast cancer.
Psychiatric side effects have included depression (5.7%) and headache (5.2%).
Respiratory side effects have included bronchitis (4.2%), sinusitis (3.8%), and upper respiratory infection (13.2%).
Metabolic side effects have included edema (3.8%) and weight gain (2.8%)
General side effects have included infection (3.3%), abdominal pain (4.2%), flu syndrome (4.7%), pain (5.2%), and accidental injury (3.3%).
Hypersensitivity side effects have included urticaria, angioedema, and anaphylactoid/anaphylactic reactions.
More estradiol/levonorgestrel resources
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