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Clorazepate Side Effects

Not all side effects for clorazepate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to clorazepate: oral capsule, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by clorazepate. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking clorazepate:

Less common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

If any of the following symptoms of overdose occur while taking clorazepate, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Some of the side effects that can occur with clorazepate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • sleeplessness
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unable to sleep
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet

General

The most commonly reported side effect was dizziness.

Psychiatric

Frequency not reported: Insomnia, suicidal ideation/behavior, irritability, depression

Nervous system

Frequency not reported: Dizziness, nervousness, headache, mental confusion, tremor, slurred speech, ataxia[Ref]

Hepatic

Frequency not reported: Abnormal liver function tests

Renal

Frequency not reported: Abnormal kidney function tests

Hematologic

Frequency not reported: Decreased hematocrit

Other

Frequency not reported: Fatigue[Ref]

Dermatologic

Frequency not reported: Transient skin rash

Cardiovascular

Frequency not reported: Decrease in systolic blood pressure

Gastrointestinal

Frequency not reported: Gastrointestinal complaints, dry mouth

Genitourinary

Frequency not reported: Genitourinary complaints

Ocular

Frequency not reported: Blurred vision, diplopia

References

1. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

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