Clorazepate Side Effects

Not all side effects for clorazepate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to clorazepate: oral capsule, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by clorazepate. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking clorazepate:

Less common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

If any of the following symptoms of overdose occur while taking clorazepate, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Some of the side effects that can occur with clorazepate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • sleeplessness
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unable to sleep
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet

Nervous system

Nervous system side effects have been common and including drowsiness, dizziness, nervousness, fatigue, confusion, and headache. Less common nervous system effects have included insomnia, irritability, delirium, diplopia, depression, tremor, and slurred speech. A case of a rage reaction has been associated with clorazepate therapy.

Other

Other side effects have included withdrawal symptoms after abrupt cessation of clorazepate. These have included agitation, restlessness, nervousness, anxiety, insomnia, convulsions, tremor, nausea, headache and sweating.

Respiratory

Respiratory side effects including respiratory depression is theoretically possible and has been reported during therapy with other benzodiazepines.

Hepatic

Hepatic side effects have included a case of jaundice followed by focal hepatocellular necrosis.

Dermatologic

Dermatologic side effects including a case of photo-onycholysis has been reported in association with clorazepate therapy. Another case of skin blistering in association with an overdose of amitriptyline and clorazepate has also been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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