Clorazepate Side Effects

Some side effects of clorazepate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to clorazepate: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking clorazepate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• confusion, unusual thoughts or behavior;

• depressed mood, thoughts of suicide or hurting yourself;

• muscle twitching, tremor; or

• problems with urination.

Less serious side effects of clorazepate may include:

• drowsiness, tiredness;

• amnesia or forgetfulness;

• dizziness;

• blurred vision;

• feeling nervous or irritable;

• sleep problems (insomnia);

• muscle weakness, lack of balance or coordination;

• skin rash;

• nausea, vomiting, stomach pain, constipation; or

• dry mouth; or

• headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to clorazepate: oral tablet

Nervous system

Nervous system side effects have been common and including drowsiness, dizziness, nervousness, fatigue, confusion, and headache. Less common nervous system effects have included insomnia, irritability, delirium, diplopia, depression, tremor, and slurred speech. A case of a rage reaction has been associated with clorazepate therapy.

Other

Other side effects have included withdrawal symptoms after abrupt cessation of clorazepate. These have included agitation, restlessness, nervousness, anxiety, insomnia, convulsions, tremor, nausea, headache and sweating.

Respiratory

Respiratory side effects including respiratory depression is theoretically possible and has been reported during therapy with other benzodiazepines.

Hepatic

Hepatic side effects have included a case of jaundice followed by focal hepatocellular necrosis.

Dermatologic

Dermatologic side effects including a case of photo-onycholysis has been reported in association with clorazepate therapy. Another case of skin blistering in association with an overdose of amitriptyline and clorazepate has also been reported.

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