Clorazepate Side Effects

Please note - some side effects for Clorazepate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Clorazepate - for the consumer

Clorazepate

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Clorazepate:

Blurred vision; clumsiness; confusion; dizziness; drowsiness; dry mouth; headache; lightheadedness; nervousness; stomach upset; unsteadiness; unusual weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

Clorazepate Sustained-Release Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Clorazepate Sustained-Release Tablets:

Blurred vision; clumsiness; confusion; dizziness; drowsiness; dry mouth; headache; lightheadedness; nervousness; stomach upset; unsteadiness; unusual weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

For the professional

Clorazepate

The side effect most frequently reported was drowsiness. Less commonly reported (in descending order of occurrence) were: dizziness, various gastrointestinal complaints, nervousness, blurred vision, dry mouth, headache, and mental confusion. Other side effects included insomnia, transient skin rashes, fatigue, ataxia, genitourinary complaints, irritability, diplopia, depression, tremor and slurred speech.

There have been reports of abnormal liver and kidney function tests and of decrease in hematocrit.

Decrease in systolic blood pressure has been observed.

By body system

Nervous system side effects

Nervous system side effects have been common and including drowsiness, dizziness, nervousness, fatigue, confusion, and headache. Less common nervous system effects have included insomnia, irritability, delirium, diplopia, depression, tremor, and slurred speech. A case of a rage reaction has been associated with clorazepate therapy.

Other side effects

Other side effects have included withdrawal symptoms after abrupt cessation of clorazepate. These have included agitation, restlessness, nervousness, anxiety, insomnia, convulsions, tremor, nausea, headache and sweating.

Respiratory side effects

Respiratory side effects including respiratory depression is theoretically possible and has been reported during therapy with other benzodiazepines.

Hepatic side effects

Hepatic side effects have included a case of jaundice followed by focal hepatocellular necrosis.

Dermatologic side effects

Dermatologic side effects including a case of photo-onycholysis has been reported in association with clorazepate therapy. Another case of skin blistering in association with an overdose of amitriptyline and clorazepate has also been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.