Clorazepate Dosage

This dosage information may not include all the information needed to use Clorazepate safely and effectively. See additional information for Clorazepate.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anxiety

Initial dose: 15 mg orally once a day at bedtime or 7.5 mg orally twice a day.
Maintenance dose: 15 to 60 mg in divided doses.
Usual dose: 15 mg orally twice a day.

Usual Adult Dose for Alcohol Withdrawal

Day 1 dose: 30 mg initially, followed by 30 to 60 mg in divided doses.
Day 2 dose: 45 to 90 mg in divided doses.
Day 3 dose: 22.5 to 45 mg in divided doses.
Day 4 dose: 15 to 30 mg in divided doses.
Then, gradually reduce the daily dose to 7.5 to 15 mg. Discontinue drug therapy as soon as patient's condition is stable.
The maximum recommended total daily dose is 90 mg.
Avoid excessive reductions in the total amount of drug administered on successive days.

Usual Adult Dose for Seizure Prophylaxis

Initial Dose: 7.5 mg orally three times a day.
Maintenance dose: May increase by 7.5 mg every week and should not exceed 90 mg/day.

Usual Geriatric Dose for Anxiety

Initial dose: 7.5 mg orally once a day at bedtime or 3.75 mg orally twice a day.
Maintenance dose: May increase as needed and tolerated.

Usual Geriatric Dose for Seizure Prophylaxis

Initial Dose: 3.75 mg orally three times a day.
Maintenance dose: May increase as needed and tolerated.

Usual Pediatric Dose for Seizure Prophylaxis

9 to less than 13 years: Initial dose: 7.5 mg orally twice a day.
Maintenance dose: May increase by no more than 7.5 mg every week and should not exceed 60 mg/day.

Less than or equal to 13 years: Initial dose: 7.5 mg orally 3 times a day.
Maintenance dose: May increase by no more than 7.5 mg every week and should not exceed 90 mg/day.

Renal Dose Adjustments

Should be used with caution in patients with renal impairment.

Liver Dose Adjustments

Should be used with caution in patients with hepatic impairment. Use in patients with hepatic failure is not recommended.

Dose Adjustments

Clorazepate 22.5 mg tablets may be administered as a single dose every 24 hours. This tablet is intended as an alternate dosage form for the convenience of patients stabilized on a dose of 7.5 mg tablets 3 times a day.

TRANXENE-SD (R) HALF STRENGTH (11.25 mg) tablets may be administered as a single dose every 24 hours. This tablet is intended as an alternate dosage form for the convenience of patients stabilized on a dose of 3.75 mg tablets three times a day. TRANXENE-SD (R) HALF STRENGTH should not be used to initiate therapy.

Dialysis

Data not available

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