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Clorazepate Dosage

Applies to the following strength(s): 3.75 mg ; 7.5 mg ; 15 mg ; 11.25 mg ; 22.5 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anxiety

Initial dose: 15 mg orally at bedtime or in divided doses
Maintenance dose: 15 to 60 mg orally in divided doses

Comments:
-In elderly or debilitated patients treatment should be initiated at a daily dose of 7.5 to 15 mg.
-Drowsiness may develop at the start of treatment and with dosage increases.

Uses:
-Management of anxiety disorders
-Short-term relief of the symptoms of anxiety

Usual Adult Dose for Alcohol Withdrawal

Day 1: 30 mg orally, followed by 30 to 60 mg in divided doses
Day 2: 45 to 90 mg orally in divided doses
Day 3: 22.5 to 45 mg orally in divided doses
Day 4: 15 to 30 mg orally in divided doses
Maximum dose: 90 mg orally per day

Comments:
-After Day 4, the daily dose should be reduced to 7.5 to 15 mg.
-Use should be discontinued as soon as patient's condition is stable.
-Excessive reductions in the total amount of drug administered on successive days should be avoided.

Use: Symptomatic relief of acute alcohol withdrawal

Usual Adult Dose for Seizure Prophylaxis

Initial Dose: 7.5 mg orally 3 times a day
Maintenance dose: May increase by no more than 7.5 mg orally every week
Maximum dose: 90 mg orally per day

Comments:
-To minimize drowsiness, the recommended initial dosages and dosage increments should not be exceeded.

Use: Adjunct to antiepileptic drugs

Usual Pediatric Dose for Seizure Prophylaxis

9 to 12 years:
Initial Dose: 7.5 mg orally 2 times a day
Maintenance dose: May increase by no more than 7.5 mg orally every week
Maximum dose: 60 mg orally per day

13 years or older:
Initial Dose: 7.5 mg orally 3 times a day
Maintenance dose: May increase by no more than 7.5 mg orally every week
Maximum dose: 90 mg orally per day

Comments:
-To minimize drowsiness, the recommended initial dosages and dosage increments should not be exceeded.

Use: Adjunct to antiepileptic drugs

Renal Dose Adjustments

Renal impairment: Use with caution

Liver Dose Adjustments

Hepatic impairment: Use with caution

Precautions

Safety and efficacy have not been established in patients younger than 9 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Storage requirements:
-Protect from moisture

Monitoring:
Psychiatric:
-Patients with a history of alcohol or drug abuse should be monitored frequently.
-Patients should be monitored for worsening and emergence of suicidal thoughts.

Patient advice:
-Patients should be cautioned accordingly since this drug may impair the mental and/or physical abilities required for the performance of operating an automobile or machinery.

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