Bupivacaine liposome Side Effects
Some side effects of bupivacaine liposome may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to bupivacaine liposome: injection suspension
Along with its needed effects, bupivacaine liposome may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine liposome:More common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- pale skin
- rapid weight gain
- tingling of the hands or feet
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- Bleeding from the anus
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- lightheadedness, dizziness, or fainting
- painful defecation
- shortness of breath
- slow or irregular heartbeat
- swelling at the surgical site
- decrease in the frequency of urination
- decrease in the urine volume
- difficult or troubled breathing
- difficulty in passing urine (dribbling)
- extra heart beat
- irregular, fast or slow, or shallow breathing
- joint pain, stiffness, or swelling
- not breathing
- painful urination
- pale or blue lips, fingernails, or skin
- pounding in the ears
- redness of the skin
- shakiness in the legs, arms, hands, or feet
- shortness of breath
- swelling at the incision site
- tightness in the chest
- troubled breathing or swallowing
Some side effects of bupivacaine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Back pain
- muscle spasm
- sleepiness or unusual drowsiness
- trouble sleeping
- unable to sleep
- Decreased appetite
- itching in the genital or other skin areas
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- cold sweats
- hives or welts
- increased sweating
- muscle weakness
- pain in the neck
- paleness of the skin
For Healthcare Professionals
Applies to bupivacaine liposome: injectable suspension
Cardiovascular side effects have included hypertension, hypotension, tachycardia, bradycardia, palpitations, sinus bradycardia, supraventricular extrasystoles, ventricular extrasystoles, procedural hypertension, procedural hypotension, and ventricular tachycardia.
Dermatologic side effects have included pruritus, rash, cold sweat, and urticaria.
Gastrointestinal side effects have included nausea (10%), constipation (10%), vomiting (10%), anal hemorrhage, painful defecation, and rectal discharge.
In general, reactions to bupivacaine are typical of those associated with other amide-type local anesthetics. A major cause of adverse reactions to these drugs is high plasma levels, which may be due to overdosage, rapid absorption from injection site, diminished tolerance, accidental intravascular injection, or slow metabolic degradation.
Genitourinary side effects have included urinary retention and urinary incontinence.
Hematologic side effects have included anemia, postoperative anemia, hemorrhagic anemia, alanine aminotransferase (ALT) increased (4%), aspartate aminotransferase (AST) increased (3%), and blood creatinine increased (2%).
Hypersensitivity side effects have included allergic-type reactions including signs such as urticaria, pruritus, erythema, angioneurotic edema (including laryngeal edema), tachycardia, sneezing, nausea, vomiting, dizziness, syncope, excessive sweating, elevated temperature, and possibly, anaphylactoid-like symptomatology (including severe hypotension).
Immunologic side effects have included fungal infection (2%).
Local side effects have included procedural pain and incision site edema (2%).
Metabolic side effects have included decreased appetite and metabolism and nutrition disorders (2%).
Musculoskeletal side effects have included muscle spasms, back pain, and muscular weakness.
Nervous system side effects have included dizziness, headache, somnolence, pallor, syncope, insomnia, pain, chills, paresthesia, tremors, and increased body temperature.
Ocular side effects have included blurred vision.
Other side effects have included a high spinal (characterized by paralysis of the legs, loss of consciousness, tinnitus, respiratory paralysis, and bradycardia) following accidental subarachnoid injection.
Psychiatric side effects have included anxiety, confused state, depression, agitation, and restlessness.
Respiratory side effects have included hypoxia, laryngospasm, apnea, respiratory depression, respiratory failure, and decreased oxygen saturation.
More about bupivacaine liposome
- Other brands: Exparel
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