Generic Name: bupivacaine liposome (bue PIV a kane LYE poe some)
Brand Names: Exparel

What is Exparel?

Exparel (bupivacaine) is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.

Exparel is used as a local (in only one area) anesthetic to numb an area of your body for a minor surgery such as bunion removal or hemorrhoid surgery.

Exparel may also be used for purposes not listed in this medication guide.

Important information

Before receiving Exparel, tell your doctor if you have liver disease, heart disease, a heart rhythm disorder, or a history of seizures.

Tell your doctor if you have ever had an allergic reaction to any type of numbing medicine.

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You will be watched closely after receiving Exparel, to make sure you do not have a reaction to the medication. Call your doctor if you have numbness, weakness, joint pain or stiffness, loss of movement, or if you still feel numb several hours after your surgery.

Before receiving Exparel

To make sure you can safely receive Exparel, tell your doctor if you have any of these other conditions:

  • liver disease;

  • kidney disease;

  • heart disease;

  • a heart rhythm disorder; or

  • a history of seizures.

FDA pregnancy category C. It is not known whether Exparel will harm an unborn baby. Before you receive this medication, tell your doctor if you are pregnant. Bupivacaine liposome can pass into breast milk and may harm a nursing baby. Before you receive Exparel, tell your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How is Exparel given?

Exparel is given as an injection placed into an area near your surgical incision. You will receive this injection in a hospital or surgical setting.

Some numbing medications can have long-lasting or delayed effects. Talk to your doctor if you have concerns about this risk. Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later.

What happens if I miss a dose?

Since Exparel is used as a single dose, it does not have a daily dosing schedule.

What happens if I overdose?

Since Exparel is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Exparel side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Exparel: hives, red rash, itching; sneezing, difficulty breathing; severe dizziness, vomiting; swelling of your face, lips, tongue, or throat. You will be watched closely after receiving Exparel, to make sure you do not have a reaction to the medication.

Tell your caregivers at once if you have any of these signs of a serious side effect:

  • ringing in your ears;

  • feeling restless or anxious;

  • feeling like you might pass out;

  • speech or vision problems, a metallic taste in your mouth;

  • numbness or tingling around your mouth;

  • tremors, twitching, mood changes;

  • fast heart rate, feeling short of breath, feeling unusually hot or cold;

  • numbness, weakness, or loss of movement where the injection was given; or

  • if you still feel numb several hours after your surgery.

Less serious Exparel side effects include:

  • mild dizziness or drowsiness;

  • nausea, vomiting;

  • constipation;

  • itching;

  • headache, back pain; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Exparel?

It is not likely that other drugs you take orally or inject will interact with a single injection of Exparel for local anesthesia. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Exparel.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2015 Cerner Multum, Inc. Version: 1.02. Revision Date: 2013-11-27, 12:08:19 PM.